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Catalog	name	Description	price
R-R-3217	Melitracen hydrochloride CAS No.10563-70-9	Melitracen hydrochloride/CAS No.10563-70-9 is an orally active biphasic antidepressant and antianxiety agent. Melitracen hydrochloride can inhibit the uptake of Norepinephrine and 5-HT (serotonin) through the presynaptic membrane inducing the increase of monoamine transmitters in synaptic space.	price>
R-C-1518	BTZ043 CAS:1161233-85-7	BTZ043 is an inhibitor of decaprenyl-phosphoribose-epimerase(DprE1),with MICs of of 2.3 nM and 9.2 nM for M.tuberculosis H37Rv and Mycobacterium smegmatis, respectively.	price>
R-R-3218	Piromelatine CAS No.946846-83-9	Piromelatine (Neu-P11)/CAS No.946846-83-9 is a melatonin MT1/MT2 receptor agonist, serotonin 5-HT1A/5-HT1D agonist, and serotonin 5-HT2B antagonist. Piromelatine (Neu-P11) possesses sleep promoting, analgesic, anti-neurodegenerative, anxiolytic and antidepressant potentials. Piromelatine (Neu-P11) also possesses pain-related P2X3, TRPV1, and Nav1.7 channel-inhibition capacities.	price>
R-C-1519	PBTZ169 CAS:1377239-83-2	Macozinone(PBTZ169)is a bactericidal benzothiazinone and a potent DprE1 (decaprenylphosphoryl-β-d-ribose 2-oxidase)inhibitor.	price>
R-R-3219	Geissoschizine methyl ether CAS No.60314-89-8	Geissoschizine methyl ether/CAS No.60314-89-8, a major indole alkaloid found in Uncaria hook, is a major active component of Yokukansan with psychotropic effects. Geissoschizine methyl ether is potent 5-HT1A receptor agonist.	price>
R-C-1520	TMS CAS:24144-92-1	TMS is a potent,selective and competitive inhibitor of cytochrome P450 1B1,an enzyme overexpressed in certain tumors(IC50=6 nM).5N/A-and 520-fold selective over P450 1A1 and 1A2 respectively.	price>
R-R-3220	Tianeptine CAS No.72797-41-2	Tianeptine/CAS No.72797-41-2 is a selective facilitator of 5-HT uptake. Tianeptine has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50>10 μM) and has no effect on noradrenalin or dopamine uptake. Tianeptine has antidepressant, anxiolytic, analgesic and neuroprotective activities.	price>
R-C-1521	Compound 401 CAS：168425-64-7	Compound 401 is a synthetic inhibitor of DNA-PK(IC50=0.28 μM) and mTOR(IC50=5.3μM).It has no inhibition on p110α/p85α PI3K(>100 μM) and blocks the phosphorylation of S6 kinase 1 Thr389 and Akt Ser473 in COS7 cells.	price>
R-R-3221	MK-212 monohydrochloride CAS No.61655-58-1	MK-212 (CPP) monohydrochloride/CAS No.61655-58-1 is a centrally acting 5-HT1C/5-HT2 agonist. MK-212 monohydrochloride can stimulate phosphoinositide hydrolysis in cerebral cortex.	price>
R-C-1522	SMER28 CAS：307538-42-7	SMER28 is a small-molecule enhancer(SMER)of autophagy,inducing autophagy independently of rapamycin in mammalian cells.	price>
R-R-3222	Vabicaserin hydrochloride CAS No.887258-94-8	Vabicaserin hydrochloride/CAS No.887258-94-8 is a 5-hydroxytryptamine 2C (5-HT2C) receptor-selective agonist with an EC50 of 8 nM.	price>
R-C-1523	AZ876 CAS:898800-26-5	AZ876 is a potent and high-affinity LXR agonist.AZ876 displays 25-fold and 2.5-fold more potent than GW3965(HY-10627)on human(h)LXRα and hLXRβ respectively.	price>
R-R-3223	Quipazine dimaleate CAS No.150323-78-7	Quipazine dimaleate/CAS No.150323-78-7 is a 5-HT agonist with a Ki value of 1.4 nM for displaces [3H]GR65630 from 5-HT3R in rat. Quipazine dimaleate shows antiviral activity against SARS-CoV-2 with an EC50 of 31.64 μM. Quipazine dimaleate behaves as a 5-HT3R antagonist in peripheral models. Quipazine dimaleate can be used for neurological disease research.	price>
R-C-1524	Paxalisib (GDC-0084) CAS:1382979-44-3	Paxalisib(GDC-0084,RG7666)is a brain penetrant inhibitor of PI3K and mTOR with Kiapp values of 2 nM,46 nM,3 nM,10 nM and 70 nM for PI3Kα,PI3Kβ,PI3Kδ,PI3Kγ and mTOR.	price>
R-R-3224	Desmethyl cariprazine CAS No.839712-15-1	Desmethyl cariprazine/CAS No.839712-15-1 is an active metabolite of Cariprazine. Cariprazine, an antipsychotic agent candidate, exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM).	price>
R-C-1525	CWHM-12 CAS:1564286-55-0	CWHM 12 can suppress all 5 alpha V integrins.CWHM12 not only worked the same way to prevent fibrosis as the genetic deletion method,it also prevent the progression of existing fibrosis in the liver and lungs and reversed some of the damage caused by fibrosis to those organs.	price>
R-R-3225	Frovatriptan succinate hydrate CAS No.158930-17-7	Frovatriptan succinate hydrate ((R)-Frovatriptan succinate hydrate)/CAS No.158930-17-7 is a potent, high affinity, selective and orally active 5-HT1B (pK50 of 8.2) and 5-HT1D receptor agonist. Frovatriptan succinate hydrate exhibits >10-fold selectivity for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1F, and 5-HT7 and >1000-fold selectivity over other 5-HT, dopamine, histamine H1, and α1-adrenoceptor. Frovatriptan succinate hydrate has the potential for migraine research.	price>
R-C-1526	ABT-639 CAS:1235560-28-7	ABT-639 is a potent and selective T-type calcium channel blocker.ABT-639 effectively reduces nociceptive and neuropathic pain in rats.ABT-639 produces robust antinociceptive activity in experimental pain models at doses that do not significantly alter psychomotor or hemodynamic function in the rat.ABT-639 was significantly less active at other Ca²⁺channels(e.g.Ca(v)1.2 and Ca(v)2.2) (IC50>30μM).ABT-639 has high oral bioavailability(%F=73),low protein binding(88.9%)and a low brain:plasma ratio(0.05:1)in rodents.	price>
R-R-3226	Fananserin CAS No.127625-29-0	Fananserin (RP 62203)/CAS No.127625-29-0 is an orally bioavailable, potent and selective 5-hydroxytryptamine2 (5-HT2) receptor antagonist, with a Ki of 0.37 nM for the rat 5-HT2A receptor. Fananserin also is a selective dopamine D4 receptor antagonist, with a Ki of 2.93 nM for the human dopamine D4 receptor.	price>
R-C-1527	SH-4-54 CAS:1456632-40-8	SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5,respectively.SH-4-54 potently kills glioblastoma brain cancer stem cells (BTSCs)and effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets at low nM concentrations.Moreover,in vivo,SH-4-54 exhibited blood-brain barrier permeability,potently controlled glioma tumor growth,and inhibited pSTAT3 in vivo.	price>

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