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Catalog	name	Description	price
R-R-3257	Ampreloxetine CAS No.1227056-84-9	Ampreloxetine (TD-9855)/CAS No.1227056-84-9 is a potent and orally active norepinephrine (NE) and serotonin 5-HT inhibitor. Ampreloxetine has the potential for the research of neurogenic orthostatic hypotension.	price>
R-C-1558	SL327 CAS：305350-87-2	SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18μM/0.2μM,no activity towards Erk1,MKK3,MKK4,c-JUN,PKC,PKA,or CamKII;capable of transport through the blood-brain barrier.	price>
R-R-3258	Amitriptyline-d6 hydrochloride CAS No.203645-63-0	Amitriptyline-d6 (hydrochloride)/CAS No.203645-63-0 is the deuterium labeled Amitriptyline hydrochloride. Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity.	price>
R-C-1559	CCG215022 CAS：1813527-81-9	CCG215022 is a potent GRK2 and GRK5 inhibitor.CCG215022 exhibited nanomolar IC50 values against both GRK2 and GRK5 and good selectivity against other closely related kinases such as GRK1 and PKA.	price>
R-R-3259	m-CPBG hydrochloride CAS No.2113-05-5	m-CPBG (1-(3-Chlorophenyl)biguanide) hydrochloride/CAS No.2113-05-5 is a selective 5-HT3 agonist. m-CPBG hydrochloride can be used for the research of neurological disease.	price>
R-C-1560	GSK-6853 CAS：1910124-24-1	GSK6853 is a potent and selective inhibitor of the BRPF1 bromodomain.shows excellent BRPF1 potency(pKd 9.5)and greater than 1600-fold selectivity over all other bromodomains tested.	price>
R-R-3260	RS 39604 CAS No.167710-87-4	RS 39604/CAS No.167710-87-4 is a potent, selective, and orally active 5-HT4 receptor antagonist with a pKi of 9.1 in guinea pig striatal membranes. RS 39604 displays a low affinity (pKi<6.5) for 5-HT1A, 5-HT2C, 5-HT3, α1c, D1, D2, M1, M2, AT1, B1 and opioid mu receptors and moderate affinity for δ1, (pKi=6.8) and δ2 (pKi=7.8) sites.	price>
R-C-1561	AM-2394 CAS：1442684-77-6	AM-2394 is a potent and selective Glucokinase agonist(GKA),which catalyzes the phosphorylation of glucose to glucose-6-phosphate.AM-2394 activates GK with an EC50 of 60 nM,increases the affinity of GK for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models,and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes.	price>
R-R-3261	Quetiapine-d4 hemifumarate CAS No.1217310-65-0	Quetiapine-d4 (hemifumarate)/CAS No.1217310-65-0 is the deuterium labeled Quetiapine hemifumarate. Quetiapine hemifumarate is a 5-HT receptors agonist and a dopamine receptor antagonist. Antidepressant and anxiolytic effects.	price>
R-C-1562	Mivebresib (ABBV-075) CAS：1445993-26-9	Mivebresib(ABBV-075)is a novel BET family bromodomain inhibitor.It binds bromodomains of BRD2/4/Twith similar affinities(Ki of 1-2.2nM)and highly selective for 18 bromodomain proteins tested (Kd>1μM;more than 600-fold selectivity vs.BRD4),but exhibits roughly 10-fold weaker potency towards BRD3 (Ki of 12.2 nM)and has moderate activity towards CREBBP(Kd=87μM;54-fold selectivity vs.BRD4).Mivebresib(ABBV-075)efficiently triggers apoptosis in various tumor cell.	price>
R-R-3262	WAY-100135 dihydrochloride CAS No.149055-79-8	WAY-100135 dihydrochloride/CAS No.149055-79-8 is a selective antagonist at presynaptic and postsynaptic 5-HT1A receptor, with an IC50 of 34 nM at the rat hippocampal 5-HT1A receptor. WAY-100135 dihydrochloride has potential antipsychotic properties.	price>
R-C-1563	Apoptozole CAS：1054543-47-3	Apoptozole(Apoptosis Activator VII)is an inhibitor of heat shock protein 70(HSP70)and Hsc70 with dissociation constants Kd of 0.14μM and 0.21μM, respectively.It induces caspase-dependent apoptosis.	price>
R-R-3263	7-Desmethyl-agomelatine CAS No.152302-45-9	7-Desmethyl-agomelatine/CAS No.152302-45-9 is a metabolite of Agomelatine. Agomelatineis a potent agonist at melatonin receptors (MT1 and MT2), and also is an antagonist of 5-HT2C.	price>
R-C-1564	go6983 CAS：133053-19-7	Go 6983 is a pan-PKC inhibitor against for PKCα,PKCβ,PKCγ,PKCδand PKCζ with IC50 of 7 nM,7 nM,6nM,10 nM and 60 nM,respectively.	price>
R-R-3264	Donitriptan CAS No.170912-52-4	Donitriptan/CAS No.170912-52-4 is a potent, high efficacy agonist at 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively.	price>
R-C-1565	Relugolix (TAK-385) CAS：737789-87-6	Relugolix(RVT-601,TAK-385)is a selective antagonist of the gonadotropin-releasing hormone receptor(GnRHR)with IC50 of 0.33 nM and 0.32 nM for human GnRHR and monkey GnRHR,respectively.	price>
R-R-3265	Strictosidinic acid CAS No.150148-81-5	Strictosidinic acid/CAS No.150148-81-5, an orally active glycoside indole monoterpene alkaloid isolated from Psychotria myriantha leaves, inhibits precursor enzymes of 5-HT biosynthesis and reduces the 5-HT levels. Strictosidinic acid has peripheral analgesic and antipyretic activities in mice.	price>
R-C-1566	Selonsertib (GS-4997) CAS：1448428-04-3	Selonsertib is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1(ASK1),with potential anti-inflammatory,antineoplastic and anti-fibrotic activities.	price>
R-R-3266	Felcisetrag CAS No.916075-84-8	Felcisetrag (TD-8954)/CAS No.916075-84-8 is an orally active, potent and selective 5-HT4 receptor agonist with gastrointestinal prokinetic properties. Felcisetrag has high affinity (pKi =9.4) for human 5-HT4(c) receptors.	price>
R-C-1567	Pamapimod CAS：449811-01-2	Pamapimod(Ro4402257)is a potent,selective and orally active p38 MAPK inhibitor with IC50s of 14 nM and 480 nM and Kis of 1.3 nM and 120 nM for p38α and p38β,respectively.Pamapimod has no activity against p38δ or p38γ isoforms.Pamapimod has the potential for rheumatoid arthritis and other autoimmune diseases treatment.	price>

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