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Catalog	name	Description	price
R-C-1708	XMD16-5 CAS:1345098-78-3	XMD16-5 is a tyrosine kinase nonreceptor 2(TNK2)inhibitor.TNK2 mutations have been found in renal cancer cells and also in lung, ovarian and gastric cancers. TNK2 genomic amplification has been associated with late stage or metastatic lung and prostate cancers.Overexpression of TNK2 promoted metastasis in a mouse model of breast cancer.	price>
R-R-3408	U92016A hydrochloride CAS No.149654-41-1	U92016A hydrochloride/CAS No.149654-41-1 is a potent, metabolically stable, orally acitive 5-HT1A receptor agonist with an exceptionally high degree of intrinsic activity. U92016A hydrochloride binds with high affinity to human 5-HT1A receptors expressed in Chinese hamster ovary cells (Ki=0.2 nM).	price>
R-C-1709	RAF-709 CAS:1628838-42-5	RAF709 is a potent inhibitor of B/C RAF kinase with almost equivalent IC50 values of 0.4nM for B-RAF and C-RAF,showing a high level of selectivity, demonstrating greater than 99% on-target binding to BRAF,BRAFV600E,and CRAF at 1 μM and very few off-targets with DDR1(>99%),DDR2(86%),FRK(92%),and PDGFRb (96%),the only kinases with binding>80% at 1μM.	price>
R-R-3409	PRX933 hydrochloride CAS No.639029-42-8	PRX933 hydrochloride/CAS No.639029-42-8 is a 5-HT2c receptor agonist extracted from patent WO 2014140631 A1.	price>
R-C-1710	MK-4101 CAS:935273-79-3	MK-4101,a potent inhibitor of the Hedgehog pathway,shows anti-tumor activity through the inhibition of proliferation and induction of extensive apoptosis in tumor cells.	price>
R-R-3410	Norfluoxetine-d5 hydrochloride CAS No.1188265-34-0	Norfluoxetine-d5 (hydrochloride)/CAS No.1188265-34-0 is deuterium labeled 3-Phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine hydrochloride.	price>
R-C-1711	BAY-876 CAS:1799753-84-6	BAY-876 is an orally active and selective glucose transporter 1 (GLUT1)inhibitor with an IC50 of 2 nM. BAY-876 is>130-fold more selective for GLUT1 than GLUT2,GLUT3,and GLUT4.BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth.	price>
R-R-3411	Bifeprunox mesylate CAS No.350992-13-1	Bifeprunox mesylate/CAS No.350992-13-1 is a potent dopamine D2-like and 5-HT1A receptor partial agonist with pKis of 7.19 and 8.83 for cortex 5-HT1A and striatum D2, and a pEC50 of 6.37 for hippocampus 5-HT1A, respectively. Bifeprunox mesylate is an antipsychotic for the research of schizophrenia.	price>
R-C-1712	CX5461 CAS:1138549-36-6	Pidnarulex(CX-5461)is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116,A375,and MIA PaCa-2 cells,has no effect on Pol II,and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.	price>
R-R-3412	CP-135807 CAS No.151272-90-1	CP-135807/CAS No.151272-90-1 is an orally active and selective 5-HT1D agonist (IC50=3.1 nM), bovine). CP-135807 mediates central psychoactivity and can be used in antidepressant research.	price>
R-C-1713	SGC 707 CAS:1687736-54-4	SGC 707 is a potent allosteric inhibitor of PRMT3(IC50=50 nM)with >100-fold selectivity over other methyltransferases and other non-epigenetic targets.	price>
R-R-3413	Vortioxetine-d8 CAS No.2140316-62-5	Vortioxetine-d8/CAS No.2140316-62-5 is a deuterium labeled Vortioxetine. Vortioxetine is an inhibitor of 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT, with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.	price>
R-C-1714	BGP-15 CAS:66611-37-8	BGP-15 is a PARP inhibitor,that can protect against heart failure and atrial fibrillation in mice.	price>
R-R-3414	Isopteropodine CAS No.5171-37-9	Isopteropodine/CAS No.5171-37-9 is heteroyohimbine-type oxindole alkaloid components of Uncaria tomentosa (Willd.) DC. Isopteropodine acts as positive modulators of muscarinic M1 and 5-HT2 receptors.	price>
R-C-1715	CNX774 CAS:1202759-32-7	CNX-774 is an orally active,irreversible and selective BTK inhibitor,with an IC50 of <1nM.CNX-774 specifically targets Cysteine 481 of Btk for covalent modification.	price>
R-R-3415	Anpirtoline hydrochloride CAS No.99201-87-3	Anpirtoline hydrochloride/CAS No.99201-87-3 is a hydrochloride of anpirtoline. Anpirtoline is a agonist of 5-HT1B.	price>
R-C-1716	Telaglenastat (CB-839) CAS:1439399-58-2	Telaglenastat(CB-839)is a potent,selective,and orally bioavailable glutaminase inhibitor with IC50 of 24nM for recombinant human GAC.CB-839(Telaglenastat)inudces autophagy and has antitumor activity.	price>
R-R-3416	Lurasidone-d8 CAS No.1132654-54-6	Lurasidone-d8/CAS No.1132654-54-6 is deuterium labeled Lurasidone. Lurasidone (SM-13496) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (SM-13496) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.	price>
R-C-1717	DDR1-IN-1 CAS:1449685-96-4	DDR1-IN-1 is a potent and selective discoidin domain receptor 1(DDR1)receptor tyrosine kinase inhibitor with IC50 of 105 nM,about 3-fold selectivity over DDR2.	price>
R-R-3417	Loxapine-d8 CAS No.1189455-63-7	Loxapine-d8/CAS No.1189455-63-7 is the deuterium labeled Loxapine.	price>

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