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Catalog	name	Description	price
R-C-1718	Remodelin CAS:949912-58-7	Remodelin is an inhibitor of N-acetyltransferase 10(NAT10),which acetylates both histones and microtubules.Remodelin improves nuclear architecture,chromatin organization,and survival of both cells lacking lamin A and cells from patients with progeria.	price>
R-R-3418	(S)-Renzapride	(S)-Renzapride ((S)-BRL 24924) is the isomer of HY-14147 Renzapride. Renzapride is a 5-HT4 receptor agonist with a Ki value of 115 nM. Renzapride also is a 5HT2b and 5HT3 receptor antagonist. Renzapride can be used for constipation predominant irritable bowel syndrome (C-IBS) study.	price>
R-C-1719	AZD5153 6-Hydroxy-2-naphthoic acid CAS:1869912-40-2	AZD-5153 6-hydroxy-2-naphthoic acid (HNT salt)is a potent,selective,and orally available BET/BRD4 bromodomain inhibitor with pKi of 8.3 for BRD4.AZD-5153 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3)target genes.NSD3,via H3K36me2, acts as an epigenetic deregulator to facilitate the expression of oncogenesis-promoting genes.	price>
R-R-3419	Cyclobenzaprine-d3 hydrochloride CAS No.1184983-42-3	Cyclobenzaprine-d3 (hydrochloride)/CAS No.1184983-42-3 is the deuterium labeled Cyclobenzaprine hydrochloride. Cyclobenzaprine hydrochloride (MK130 hydrochloride) is a skeletal muscle relaxant and a central nervous system (CNS) depressant.	price>
R-C-1720	AZD0156 CAS:1821428-35-6	AZD0156 is a potent and selective inhibitors of ATM kinase,with potential chemo-/radio-snsitizing and antineoplastic activities.AZD0156 prevents DNA damage checkpoint activation,disrupts DNA damage repair,induces tumor cell apoptosis,and leads to cell death of ATM-overexpressing tumor cells.	price>
R-R-3420	LY 344864 S-enantiomer CAS No.186544-27-4	LY 344864 S-enantiomer/CAS No.186544-27-4 is the S-enantiomer of LY344864. LY344864 is a 5-HT1F receptor agonist.	price>
R-C-1721	ISCK03 CAS:945526-43-2	ISCK03(N-(4-imidazol-1-yl phenyl)sulfonamide)is a cell-permeable inhibitor of stem-cell factor(SCF)/c-kit signaling.ISCK03 inhibits SCF-induced c-c-kit phosphorylation and downstream ERK phosphorylation.	price>
R-R-3421	Perphenazine-d4 CAS No.155593-75-2	Perphenazine-d4/CAS No.155593-75-2 is the deuterium labeled Perphenazine. Perphenazine is a typical antipsychotic agent, inhibits 5-HT2Areceptor, Alpha-1A adrenergic receptor, Dopamine receptor D2/D3, D2L receptor, and Histamine H1 receptor, with Ki values of 5.6, 10, 0.765/0.13, 3.4, and 8 nM, respectively.	price>
R-C-1722	PD-166866 CAS:192705-79-6	PD166866 is a FGFR1 inhibitor with IC50 value of 55 nM,and no effect on c-Src, PDGFR-b,EGFR or insulin receptor tyrosine kinases or MEK,PKC,and CDK4.	price>
R-R-3422	3-Hydroxy agomelatine-d3 CAS No.1079774-23-4	3-Hydroxy agomelatine-d3/CAS No.1079774-23-4 is a deuterium labeled 3-Hydroxy agomelatine. 3-Hydroxy agomelatine is a 5-HT2C receptor antagonist with an IC50 of 3.2 μM and a Ki of 1.8 μM.	price>
R-C-1723	AZD9496 CAS:1639042-08-2	AZD9496 is a potent and orally bioavailable selective estrogen receptor downregulator and antagonist.	price>
R-R-3423	Eplivanserin (mixture) CAS No.130581-13-4	Eplivanserin mixture (SR-46349 mixture)/CAS No.130581-13-4 is a selective serotonin reuptake inhibitor and a 5-HT2A receptor antagonist, extracted from patent WO 2005/002578 A1.	price>
R-C-1724	Dastroline(Epinastine) CAS: 80012-43-7	Emedastine is a potent,high affinity histamine H1-receptor-selective antagonist with Ki of 1.3±0.1nM for H1-receptors while considerably weaker at H2-(K1=49,067±11,113nM) and H3-receptors(Ki=12,430±1,282nM).	price>
R-R-3424	3-AQC CAS No.201216-42-4	3-AQC/CAS No.201216-42-4, a piperazinylquinoxaline derivative, is a potent and competitive 5-HT3 receptor antagonist.	price>
R-C-1725	Peficitinib CAS: 944118-01-8	Peficitinib is a novel potent JAK inhibitor,which demonstrated potent efficacy in adjuvant-induced arthritis model in rats.	price>
R-R-3425	Ondansetron-13C,d3 CAS No.2699607-85-5	Ondansetron-13C,d3/CAS No.2699607-85-5 is the 13C- and deuterium labeled Ondansetron.	price>
R-C-1726	Vemurafenib (PLX4032) CAS:918504-65-1	Vemurafenib(PLX4032,RG7204,RO5185426)is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM in cell-free assay.10-fold selective for B-RafV600E over wild-type B-Raf in enzymatic assays and the cellular selectivity can exceed 100-fold.Vemurafenib(PLX4032,RG7204)induces autophagy.	price>
R-R-3426	Brexpiprazole-d8 CAS No.1427049-21-5	Brexpiprazole-d8/CAS No.1427049-21-5 is a deuterium labeled Brexpiprazole (OPC-34712). Brexpiprazole, an atypical antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine receptor (Ki=0.12 nM and 0.3 nM, respectively). Brexpiprazole is also a 5-HT2A receptor antagonist (Ki=0.47 nM).	price>
R-C-1727	Boceprevir (SCH-503034) CAS:394730-60-0	Boceprevir(EBP 520)is a potent, highly selective,orally bioavailable HCV NS3 protease inhibitor with a Ki of 14nM in both enzyme assay and an EC90 of 350nM in cell-based replicon assay.Boceprevir inhibits SARS-CoV-2 3CLpro activity.	price>
R-R-3427	Agomelatin-d3 CAS No.1079389-38-0	Agomelatin-d3/CAS No.1079389-38-0 is the deuterium labeled Agomelatine. Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively.	price>

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