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Catalog	name	Description	price
R-R-3561	Adenosine A1 receptor activator T62 CAS No.40312-34-3	Adenosine A1 receptor activator T62/CAS No.40312-34-3 is an allosteric enhancer of adenosine A1 receptor. Adenosine A1 receptor activator T62 produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve-injury pain.	price>
R-C-1862	NG25 CAS:1315355-93-1	NG-25 is a type II kinase inhibitor that inhibits MAP4K2 and TAK1.It also inhibits the Src family kinases Src and LYN and Abl family kinases as well as CSK,FER,and p38.NG 25 prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells.It inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097,respectively.NG 25 decreases cell viability of HCT116KRASWT,and to a greater degree of HCT116KRASG13D, colorectal cancer cells in a concentration-dependent manner.It also reduces tumor growth and increases the number of TUNEL-positive tumor cells in a CT26KRASG12D mouse orthotopic model of colorectal cancer.	price>
R-R-3562	Tecadenoson CAS No.204512-90-3	Tecadenoson (CVT-510)/CAS No.204512-90-3 is a selective A1 adenosine receptor agonist.	price>
R-C-1863	Vecabrutinib (SNS-062) CAS:1510829-06-7	Vecabrutinib(SNS-062)is a potent,noncovalent BTK and ITK inhibitor, with Kd values of 0.3 nM and 2.2nM,respectively.Vecabrutinib shows an IC50 of 24 nM for ITK.	price>
R-R-3563	CV1808 CAS No.53296-10-9	CV1808 (2-Phenylaminoadenosine)/CAS No.53296-10-9 is a non-selective A2 adenosine receptor (A2 AR) agonist with Kis of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively.	price>
R-C-1864	BAY 61-3606 CAS:732983-37-8	BAY 61-3606 is an orally available,ATP-competitive,reversible and highly selective Syk inhibitor with a Ki of 7.5nM and an IC50 of 10nM.BAY 61-3606 reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell.BAY 61-3606 induces a large decrease of Syk phosphorylation in K-rn cell lysates.Bay 61-3606 sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.	price>
R-R-3564	FR194921 CAS No.202646-80-8	FR194921/CAS No.202646-80-8 is a potent, selective and orally active and cross the blood-brain barrier Adenosine A1 antagonist with Ki value of 6.6, 5400 nM for A1, A2A, respectively. FR194921 shows cognitive-enhancing and anxiolytic activity.	price>
R-C-1865	Takinib CAS:1111556-37-6	Takinib(EDHS-206)is a potent and selective TAK1 inhibitor with an IC50 of 9.5 nM,more than 1.5 log more potent than the second and third ranked targets,IRAK4(120 nM)and IRAK1(390 nM),respectively.Takinib induces apoptosis.	price>
R-R-3565	HEMADO CAS No.403842-38-6	HEMADO/CAS No.403842-38-6 is a potent and selective adenosine A3 receptor agonist with a Ki of 1.1 nM at the human A3 subtype. HEMADO is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-1866	BAY1895344 CAS:1876467-74-1	Elimusertib(BAY-1895344)is a very potent and highly selective ATR(ataxia telangiectasia and Rad3-related)inhibitor with IC50 of 7nM Elimusertib potently inhibits proliferation of a broad spectrum of human tumor cell lines with median IC50 of 78nM.	price>
R-R-3566	MRE3008F20 CAS No.252979-43-4	MRE3008F20/CAS No.252979-43-4 is a highly potent and selective adenosine A3 receptor (AA3R) antagonist that inhibits agonist-induced cAMP elevation in resting T cells with an IC50 of 5 nM.	price>
R-C-1867	JNJ-46778212(VU 0409551) CAS:1363281-27-9	JNJ-46778212(VU 0409551)is an mGlu5 positive allosteric modulator with an EC50 of 260nM.	price>
R-R-3567	VUF-5574 CAS No.280570-45-8	VUF-5574/CAS No.280570-45-8 is a selective antagonist of adenosine A3 receptor with a Ki of 4.03 nM for the recombinant human receptor.	price>
R-C-1868	PRT-060318(PRT318) CAS:1194961-19-7	PRT-060318(PRT318)is a novel selective inhibitor of the tyrosine kinase Syk with an IC50 of 4nM.	price>
R-R-3568	Enprofylline CAS No.41078-02-8	Enprofylline/CAS No.41078-02-8 acts as a selective and competitive A2B receptor antagonist with the Ki of 7 μM. Enprofylline also acts as a phosphodiesterase inhibitor. Enprofylline can be used for the research of asthma, chronic obstructive pulmonary disease.	price>
R-C-1869	3-TYP CAS:120241-79-4	3-TYP is a selective SIRT3 inhibitor,with an IC50 of 16 nM,more potent over SIRT1(IC50=88nM),SIRT2(IC50=92nM).	price>
R-R-3569	KI-7 CAS No.1489263-00-4	KI-7/CAS No.1489263-00-4 is an A2B adenosine receptor positive allosteric modulator. KI-7 potentiates the cAMP accumulation induced by the non-selective A2B adenosine receptor agonist NECA (EC50=445.8 nM). KI-7 also potentiates the cAMP accumulation induced by the selective A2B adenosine receptor agonist BAY 60-6583 as well as by adenosine with EC50s of 2390 nM and 2550 nM, respectively.	price>
R-C-1870	DDP-38003 dihydrochloride CAS:1831167-98-6	DDP-38003 dihydrochloride is an novel,orally available inhibitor of histone lysine-specific demethylase 1A(KDM1A/LSD1)with an IC50 of 84nM.	price>
R-R-3570	Doxofylline-d6 CAS No.1219805-99-8	Doxofylline-d6/CAS No.1219805-99-8 is the deuterium labeled Doxofylline. Doxofylline is an antagonist of adenosine A1 receptor which also inhibits phosphodiesterase IV.	price>
R-C-1871	Tropifexor (LJN452) CAS:1383816-29-2	Tropifexor(LJN452)is a novel and highly potent agonist of FXR with EC50 of 0.2 nM in HTRF assay.It shows no significant off-target activity against a broad panel of enzyme,ion channel,nuclear receptor,and GPCR(>10000-fold selectivity for FXR).	price>

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