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Catalog	name	Description	price
R-C-1845	SGI7079 CAS:1239875-86-5	SGI-7079,a novel selective Axl inhibitor with an IC50 of 58 nM in vitro, inhibits tumor growth in a dose dependent manner and is a potential therapeutic target for overcoming EGFR inhibitor resistance.	price>
R-C-1846	BI-882370 CAS:1392429-79-6	BI-882370 is a potent and selective RAF kinase inhibitor that binds to the ATP binding site of the kinase positioned in the DFG-out(inactive)conformation of the BRAF kinase.BI-882370(BI 882370)inhibits the oncogenic BRAFV600E-mutant,the WT BRAF and CRAF kinases with IC50s of 0.4,0.8,and 0.6nM,respectively.BI-882370 also inhibits SRC family kinases.	price>
R-R-3546	Adenosine amine congener CAS No.96760-69-9	Adenosine amine congener (ADAC)/CAS No.96760-69-9 is a selective A1 adenosine receptor agonist, can ameliorate noise- and Cisplatin-induced cochlear injury. Adenosine amine congener also has neuroprotective effects.	price>
R-C-1847	TP808 CAS:852821-06-8	TP808 is a useful intermediate for the synthesis of diverse tetracycline antibiotics.	price>
R-R-3547	MRS1220 CAS No.183721-15-5	MRS1220/CAS No.183721-15-5, a highly potent and selective human A3 adenosine receptor (hA3AR) antagonist with a Ki of 0.59 nM, has therapeutic potential for the research of diseases of the central nervous system. MRS1220 reduces glioblastoma tumor size and blood vessel formation in vivo.	price>
R-C-1848	PST-2744 (Istaroxime) CAS：203737-94-4,203737-93-3	Istaroxime（PST-2744)is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase(Na+/K+ ATPase). Na+/K+ATPase inhibition increases intracellular sodium levels,which reverses the driving force of the sodium/calcium exchanger,inhibiting calcium extrusion and possibly facilitating calcium entry.	price>
R-R-3548	PSB36 CAS No.524944-72-7	PSB36/CAS No.524944-72-7 is a potent and selective antagonist of adenosine A1 receptor, with Kis 0.12 nM, 187 nM, 552 nM, 2300 nM, and 6500 nM for rA1, hA2B, rA2A, hA3 and rA3 receptors respectively. PSB36 can be used for the research of hyperalgesia.	price>
R-C-1849	TP353 CAS：1253799-29-9	TP353(EOS-61973)is an inhibitor of CDK7.	price>
R-R-3549	Theophylline-d6 CAS No.117490-39-8	Theophylline-d6/CAS No.117490-39-8 is the deuterium labeled Theophylline. Theophylline is a nonselective phosphodiesterase (PDE) inhibitor, adenosine receptor blocker, and histone deacetylase (HDAC) activator.	price>
R-C-1850	CG347B CAS:1598426-03-9	CG347B is a selective inhibitor of HDAC6.	price>
R-R-3550	LUF6000 CAS No.890087-21-5	LUF6000/CAS No.890087-21-5 is an orally active allosteric modulator of the A3 adenosine receptor. LUF6000 has potent anti-inflammatory effect.	price>
R-C-1851	Tinostamustine(EDO-S101) CAS:1236199-60-2	EDO-S101(Tinostamustine)is a pan HDAC inhibitor; inhibits HDAC6,HDAC1,HDAC2 and HDAC3 with IC50 values of 6nM,9nM,9nM and 25nM,respectively.	price>
R-R-3551	A2B receptor antagonist 2 CAS No.784-90-7	A2B receptor antagonist 2 (compound 18)/CAS No.784-90-7 is an adenosine receptor A2B antagonist, with Ki values of 2.30 μM, 6.8 μM and 3.44 μM for rA1, rA2A and hA2B, respectively.	price>
R-C-1852	TP-4748 CAS:1150114-62-7	TP-4748 is a biochemical.	price>
R-R-3552	PSB 0777 ammonium hydrate	PSB 0777 ammonium hydrate is a potent and selective adenosine A2A receptor full agonist with Ki values of 44.4 nM, 360 nM for rat and human A2A receptors, respectively. PSB 0777 ammonium hydrate has Ki values of ≥10000 nM, 541 nM for rat and human A1 receptors, respectively. PSB 0777 ammonium hydrate shows poor brain penetrant and perorally non-absorbable effect. PSB 0777 ammonium hydrate has the potential for inflammatory bowel disease (IBS) research research.	price>
R-C-1853	DBPR114 CAS：2443767-35-7	DBPR114 is a potent multi-kinase inhibitor with potent activities against more than 57 oncogenic kinases,including Aurora-A,FLT3,CSF1R,MET,etc.DBPR114 exhibited favorable PK profiles:a long half-life(t1/2 =23.5h),moderate clearance and high volume of distribution.Also DBPR114 can effectively inhibit the growth of human acute myeloid leukemia MOLM-13 and MV4-11,MIA PaCa-2,Hep3B, MKN45,Colo205,and NTUB1 solid tumor xenografts in vivo without causing significant body weight loss.	price>
R-R-3553	ANR94 CAS No.634924-89-3	ANR94/CAS No.634924-89-3 is a potent and selective adenosine A2A receptor (AA2AR) antagonist with an Ki of 46 nM for hAA2AR. ANR94 has the potential for the research of Parkinson disease.	price>
R-C-1854	TP748 CAS:951698-15-0	TP748 is a bioactive chemical.	price>
R-R-3554	Xanthine amine congener hydrochloride CAS No.1783977-95-6	Xanthine amine congener (XAC) hydrochloride/CAS No.1783977-95-6 is a non-selective adenosine receptor antagonist. Xanthine amine congener hydrochloride induces convulsions in mice.	price>
R-C-1855	THZ2 CAS:1604810-84-5	THZ2,a THZ1 analog,is a selective inhibitor of CDK7 with IC50 of 13.9 nM.THZ2 efficiently suppresses the clonogenic growth of TNBC cells with IC50 of ~10nM.	price>

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