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Catalog	name	Description	price
R-C-1887	Opaganib (ABC294640) CAS：915385-81-8	ABC294640 is an orally available,aryladamantane compound and selective inhibitor of sphingosine kinase-2(SK2)with potential antineoplastic activity.	price>
R-R-3587	Adenosine receptor antagonist 4 CAS No.133240-06-9	Adenosine receptor antagonist 4 (compound 2)/CAS No.133240-06-9 is an adenosine A1 receptor antagonist with a Ki of 101 nM for human A1 receptor.	price>
R-C-1888	CB-03-01 CAS：19608-29-8	Clascoterone(Winlevi,Cortexolone 17 alpha-propionate,Cortexolone 17α-propionate, CB-03-01)is a topical and peripherally selective antagonist of androgen receptor(AR).	price>
R-R-3588	FSCPX CAS No.156547-56-7	FSCPX/CAS No.156547-56-7 is a potent and selective irreversible antagonist of A1 adenosine receptor (A1AR), with low nanomolar potency for binding to the A1AR. FSCPX could modify the effect of NBTI, a nucleoside transport inhibitor, by reducing the interstitial adenosine level in the guinea pig atrium.	price>
R-C-1889	Sapacitabine CAS：151823-14-2	Sapacitabine is hydrolyzed by amidases to the deoxycytosine analogue CNDAC(2-Cyano-2-deoxyarabinofuranosylcytosine),which is then phosphorylated into the active triphosphate form.As an analogue of deoxycytidine triphosphate,CNDAC triphosphate incorporates into DNA strands during replication,resulting in single-stranded DNA breaks during polymerization due to beta-elimination during the fidelity checkpoint process; cell cycle arrest in the G2 phase and apoptosis ensue.	price>
R-R-3589	Salmeterol CAS No.89365-50-4	Salmeterol (GR33343X)/CAS No.89365-50-4 is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively.	price>
R-C-1890	Pritelivir (BAY 57-1293） CAS：348086-71-5	BAY 57-1293 is a potent helicase primase inhibitor.BAY 57-1293 inhibits replication of herpes simplex virus(HSV)type 1 and type 2 in the nanomolar range in vitro by abrogating the enzymatic activity of the viral primase-helicase complex.	price>
R-R-3590	Phenylacetylglycine CAS No.500-98-1	Phenylacetylglycine/CAS No.500-98-1 is a gut microbial metabolite that can activate β2AR. Phenylacetylglycine protects against cardiac injury caused by ischemia/reperfusion.	price>
R-C-1891	Acalabrutinib（ACP-196） CAS:1420477-60-6	Acalabrutinib(ACP-196)is a selective second-generation Bruton is tyrosine kinase(BTK)inhibitor with an IC50 of 3nM,which prevents the activation of the B-cell antigen receptor(BCR)signaling pathway.ACP-196 has improved target specificity over ibrutinib with 323-,94-,19-and 9-fold selectivity over the other TEC kinase family members(ITK,TXK,BMX,and TEC,respectively)and no activity against EGFR.	price>
R-C-2251	Resibufogenin CAS：465-39-4	Resibufogenin(Bufogenin,Recibufogenin),a component of huachansu with anticancer effect,triggers necroptosis through upregulating receptor-interacting protein kinase 3(RIP3)and phosphorylating mixed lineage kinase domain-like protein at Ser358.Resibufogenin exerts cytotoxic effect by inducing reactive oxygen species(ROS)accumulation.Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity.	price>
R-R-3591	Dexmedetomidine hydrochloride CAS No.145108-58-3	Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride)/CAS No.145108-58-3 is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects.	price>
R-C-1892	Doravirine (MK-1439) CAS：1338225-97-0	Doravirine(MK-1439)is a highly specific HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50s of 4.5 nM,5.5nM and 6.1nM against the wild type and K103N and Y181C reverse transcriptase mutants.	price>
R-C-2252	Daphnoretin CAS： 2034-69-7	Daphnoretin(Dephnoretin,Thymelol),a biologically active compound isolated from Wikstroemia indica C.A.Mey.,is a protein kinase C(PKC)activator.Daphnoretin inhibits the proliferation,invasion,and migration of tumor cells and promote its apoptosis by regulating the activity of Akt signal pathway.	price>
R-R-3592	Dobutamine hydrochloride CAS No.49745-95-1	Dobutamine hydrochloride/CAS No.49745-95-1 is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion.	price>
R-C-1893	Fostemsavir(BMS-663068) CAS：864953-29-7	Fostemsavir(BMS-663068,Rukobia),the phosphonooxymethyl prodrug of BMS626529,is an attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells with EC50 of<10nM.	price>
R-C-2253	Neferine CAS：2292-16-2	Neferine((R)-1,2-Dimethoxyaporphine),a natural component of Nelumbo nucifera, has antitumor efficiency,Neferine induces apoptosis in renal cancer cells. Neferine prevents autophagy through activation of Akt/mTOR pathway and Nrf2 in muscle cells.Neferine strongly inhibits NF-κB activation.	price>
R-R-3593	Atomoxetine hydrochloride CAS No.82248-59-7	Atomoxetine (Tomoxetine) hydrochloride/CAS No.82248-59-7 is a selective noradrenaline reuptake inhibitor with Ki values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na+ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research.	price>
R-C-1894	Nazartinib(EGF816) CAS：1508250-71-2	Nazartinib(EGF816,NVS-816)is a covalent,irreversible,mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt(L858R,ex19del)and T790M mt,with up to 60-fold selectivity over wild type(wt)EGFR in vitro.	price>
R-C-2254	LM22B-10 CAS：342777-54-2	LM22B-10 is a TrkB and TrkC agonist.LM22B-10 exhibits neurotrophic activity .	price>
R-R-3594	Terazosin hydrochloride dihydrate CAS No.70024-40-7	Terazosin hydrochloride dihydrate/CAS No.70024-40-7 is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin hydrochloride dihydrate works by relaxing blood vessels and the opening of the bladder. Terazosin hydrochloride dihydrate has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment.	price>

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