Xi'an ruixi Biological Technology Co

Home > Keywords >

Catalog	name	Description	price
R-C-1895	LOXO-101（Larotrectinib） CAS：1223403-58-4	Larotrectinib(LOXO-101)is an ATP-competitive oral,selective inhibitor of the tropomyosin-related kinase(TRK)family receptors,with low nanomolar 50% inhibitory concentrations against all three isoforms(TRKA,B,and C).	price>
R-C-2255	Amarogentin CAS：21018-84-8	Amarogentin(AG),a secoiridoid glycoside mainly extracted from Swertia and Gentiana roots,exhibits anti-oxidative,anti-tumour,and anti-diabetic activities.Amarogentin is an agonist for the bitter taste receptor TAS2R1 and inhibits in LAD-2 cells substance P-induced production of newly synthesized TNF-α.Amarogentin induces apoptosis in human gastric cancer cells(SNU-16)through G2/M cell cycle arrest and PI3K/Akt signalling pathway.	price>
R-R-3595	Clonidine CAS No.4205-90-7	Clonidine/CAS No.4205-90-7 is an alpha 2-adrenergic agonist.	price>
R-C-1896	Glecaprevir CAS：1365970-03-1	Glecaprevir(ABT-493,A-1282576)is a novel HCV NS3/4A protease inhibitor,with IC50 values ranging from 3.5 to 11.3nM.	price>
R-C-2256	Homosalate CAS：118-56-9	Homosalat(HMS,Homomenthyl salicylate)is an organic ultraviolet filter used in most sunscreens but has been reported to be toxic to marine organisms. Homosalate aggravates the invasion of human trophoblast cells as well as regulates intracellular signaling pathways including PI3K/AKT and MAPK pathways.	price>
R-R-3596	Tamsulosin CAS No.106133-20-4	Tamsulosin ((R)-(-)-YM12617 free base)/CAS No.106133-20-4 is an inhibitor of α1-adrenergic receptor. Tamsulosin is used for the research of prostatic hyperplasia. Tamsulosin attenuates abdominal aortic aneurysm growth in animal models.	price>
R-C-1897	Valbenazine CAS:1025504-45-3	Valbenazine（NBI-98854 and MT-5199)is a potent and selective VMAT2 inhibitor. NBI-98854 is effective in regulating the levels of dopamine release during nerve communication,while at the same time having minimal impact on the other monoamines.NBI-98854 is promising agent for the treatment of tardive dyskinesia.NBI-98854 significantly improved tardive dyskinesia and was well tolerated in patients.These results support the phase 3 clinical trials of NBI-98854 now underway.	price>
R-C-2257	Alobresib (GS-5829) CAS：1637771-14-2	Alobresib(GS-5829)is a novel BET inhibitor that represents a highly effective therapeutics agent against recurrent/chemotherapy-resistant USC-overexpressing c-Myc.Alobresib(GS-5829)inhibits CLL cell proliferation and induces leukemia cell apoptosis through deregulation of key signaling pathways,such as BLK,AKT,ERK1/2,and MYC.Alobresib (GS-5829)also inhibits NF-κB signaling.	price>
R-R-3597	SR59230A hydrochloride CAS No.1135278-41-9	SR59230A hydrochloride/CAS No.1135278-41-9 is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively.	price>
R-C-1898	AS703026 CAS：1236699-92-5	AS703026 is a novel,selective,orally bioavailable MEK1/2 inhibitor that inhibits growth and survival of MM cells and cytokine-induced osteoclast differentiation.	price>
R-C-2258	Ailanthone CAS：981-15-7	Ailanthone(AIL,Δ13-Dehydrochaparrinone),a natural anti-hepatocellular carcinoma (HCC)component in Ailanthus altissima,induces G0/G1-phase cell cycle arrest by decreasing expression of cyclins and CDKs and increases expression of p21 and p27.Ailanthone triggers DNA damage characterized by activation of the ATM/ATR pathway.Ailanthone induces apoptosis which is mitochondrion-mediated and involves the PI3K/AKT signaling pathway in Huh7 cells.	price>
R-R-3598	Guanfacine hydrochloride CAS No.29110-48-3	Guanfacine hydrochloride/CAS No.29110-48-3 is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette syndrome and attention deficit hyperactivity disorder (ADHD).	price>
R-C-1899	C188-9 CAS：432001-19-9	C188-9(TTI 101)is a potent inhibitor of STAT3 that binds to STAT3 with high affinity(KD=4.7±0.4nM).C188-9 is well tolerated in mice,shows good oral bioavailability,and is concentrated in tumors.	price>
R-C-2259	Methyl-Hesperidin CAS：11013-97-1	Methyl Hesperidin is a flavanone glycoside(flavonoid)(C28H34O15)found abundantly in citrus fruits.Its aglycone form is called hesperetin.	price>
R-R-3599	L748337 CAS No.244192-94-7	L748337/CAS No.244192-94-7 is a potent β3-adrenergic receptor antagonist and displays selectivity over β1 and β2 receptors. The Ki values of L748337 for β3-, β2- and β1-adrenoceptors are 4.0 nM, 204 nM and 390 nM, respectively. L748337 couples predominantly to Gi to activate MAPK signaling and increases phosphorylation of Erk1/2 with pEC50 value of 11.6. L748337 can be used for the research of cancer, nonalcoholic fatty liver disease (NAFLD), and cardiovascular related diseases.	price>
R-C-1900	BD1063 HCl CAS：206996-13-6	BD1063 2HCL(BD1063 dihydrochloride)is a potent and selective sigma-1 receptor (σ1R)antagonist with Ki of 4.43nM.	price>
R-C-2260	Dinaciclib (SCH727965) CAS：779353-01-4	Dinaciclib(SCH727965,PS-095760)is a novel and potent CDK inhibitor for CDK2,CDK5,CDK1 and CDK9 with IC50 of 1nM,1nM,3nM and 4nM in cell-free assays,respectively.It also blocks thymidine(dThd)DNA incorporation.Dinaciclib induces apoptosis through the activation of caspases 8 and 9.	price>
R-R-3600	Atipamezole hydrochloride CAS No.104075-48-1	Atipamezole (MPV-1248) hydrochloride/CAS No.104075-48-1 is a potent α2-adrenoceptor antagonist with a Ki of 1.6 nM.	price>
R-C-1901	SF 2523 CAS：1174428-47-7	SF2523 is a highly selective and potent inhibitor of PI3K with IC50 values of 34 nM,158nM,9nM,241nM and 280nM for PI3Kα,PI3Kγ,DNA-PK,BRD4 and mTOR, respectively.	price>
R-C-2261	Flavopiridol (L86-8275) CAS：146426-40-6	Flavopiridol(L86-8275,Alvocidib,NSC 649890,HMR-1275)competes with ATP to inhibit CDKs including CDK1,CDK2,CDK4,CDK6,and CDK9 with IC50 values in the 20-100nM range.It is more selective for CDK1,2,4,6,9 versus CDK7.Flavopiridol is initially found to inhibit EGFR and PKA.Flavopiridol induces autophagy and ER stress.Flavopiridol blocks HIV-1 replication.	price>

572573574575576577 578579580581582