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Catalog	name	Description	price
R-R-3809	(RS)-Butyryltimolol CAS No.2320274-78-8	(RS)-Butyryltimolol/CAS No.2320274-78-8 is the racemate of Butyryltimolol. Butyryltimolol, an effective proagent of Timolol, improves the corneal penetration of Timolol. Butyryltimolol is a β-adrenergic blocker.	price>
R-C-2110	LUT-014 CAS：2274819-46-2	LUT014 is a B-Raf inhibitor with an IC50 of 11.7nM,and developed to reduce dose-limiting acneiform lesions associated EGFR Inhibitors treatment.Extracted from patent WO 2019026065A2.	price>
R-R-3810	Solabegron CAS No.252920-94-8	Solabegron (GW 427353)/CAS No.252920-94-8 is a selective β3-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR, with an EC50 value of 22 nM. Solabegron (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome.	price>
R-C-2111	Spastazoline CAS：2351882-11-4	Spastazoline is a potent,cell-permeable and selective spastin(a microtubule-severing AAA(ATPases associated with diverse cellular activities) protein)inhibitor with IC50 of 99nM for Human spastin.Spastazoline does not inhibit ATPase activity of a recombinant human VPS4(another AAA protein required for intercellular bridge disassembly).	price>
R-R-3811	Scopine CAS No.498-45-3	Scopine/CAS No.498-45-3 is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.	price>
R-C-2112	KL1333 CAS：1800405-30-4	KL1333,a derivative of β-lapachone,is an orally available NAD+modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1(NQO1)as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation.KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts.KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures.	price>
R-R-3812	Carbazochrome sodium sulfonate CAS No.51460-26-5	Carbazochrome sodium sulfonate (AC-17)/CAS No.51460-26-5 is a capillary stabiliser and used for the research of haemorrhage. Carbazochrome sodium sulfonate is an antihemorrhagic agent.	price>
R-C-2113	VUN34002（Vanin-1-IN-1 ） CAS：2173134-00-2	Vanin-1-IN-1 is an inhibitor of vanin-1 enzyme which is a cell surface associated,giycosyiphosphatidyS inositol(GPi)anchored protein and plays an important role in metabolism and inflammation.	price>
R-R-3813	(+)-Penbutolol CAS No.38363-41-6	(+)-Penbutolol/CAS No.38363-41-6 is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM. (+)-Penbutolol is an optical isomer of l-penbutolol with Na+ channel-blocking action.	price>
R-C-2114	Danicopan CAS： 1903768-17-1	Danicopan(ACH-4471,ACH-0144471,ACH-CFDIS,ALXN 2040)is a potent,selective and orally active inhibitor of factor D with Kd of 0.54nM for human Factor D. Danicopan inhibits alternative pathway of complement(APC)activity,and has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria(PNH)and atypical hemolytic uremic syndrome(aHUS).	price>
R-R-3814	Todralazine hydrochloride CAS No.3778-76-5	Todralazine hydrochloride (Ecarazine hydrochloride)/CAS No.3778-76-5 is an anti-hypertensive agent, acts as a β2AR blocker, with antioxidant and free radical scavenging activity.	price>
R-C-2115	LML-134 CAS：1542135-76-1	LML134(compound 18b)is an orally active and high selective Histamine 3 receptor (H3R)inverse agonist with Kis of 0.3nM and 12nM for hH3R cAMP and hH3R bdg. LML134 penetrates the brain rapidly,leading to high H3R occupancy,and disengages its target with a fast kinetic profile.LML134 has the potential for excessive sleep disorders.	price>
R-R-3815	Bufuralol hydrochloride CAS No.60398-91-6	Bufuralol (Ro 3-4787) hydrochloride/CAS No.60398-91-6 is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate.	price>
R-R-3816	Tasipimidine sulfate CAS No.1465908-73-9	Tasipimidine sulfate/CAS No.1465908-73-9 is an orally active and selective α2A-adrenoceptor agonist with a pEC50 of 7.57 against human α2A-adrenoceptor. Tasipimidine sulfate can be used for situational anxiety and fear research.	price>
R-C-2117	EOAI3402143 CAS：1699750-95-2	EOAI3402143 is a novel dose-dependent inhibitor of Usp9x and Usp24 activity, increasing tumor cell apoptosis and fully blocking or regressing myeloma tumors in mice.	price>
R-R-3817	Propranolol-d7 (ring-d7) CAS No.344298-99-3	Propranolol-d7 (ring-d7)/CAS No.344298-99-3 is the deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.	price>
R-C-2118	GS-4361 CAS：2291164-02-6	GS-4361 is a potent and selective IDO1 inhibitor with an EC50 of 17nM,GS-4361 was first reported in patent WO2019040102A.	price>
R-R-3818	4-Hydroxyatomoxetine CAS No.435293-66-6	4-Hydroxyatomoxetine/CAS No.435293-66-6 is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6). Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5 nM, 77 nM and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively).	price>
R-C-2119	NTN21277（Gefitinib-based PROTAC 3） CAS：2230821-27-7	NTN21277（Gefitinib-based PROTAC 3 )is a VHL-recruiting PROTAC that induces the degradation of EGFR and EGFR mutants with DC50 of 11.7nM and 22.3nM for HCC827 cell(Exon 19 del)and H3255 cell(L858R).	price>
R-R-3819	Zinterol hydrochloride CAS No.38241-28-0	Zinterol hydrochloride (MJ 9184 hydrochloride)/CAS No.38241-28-0 is a potent and selective β2-adrenoceptor agonist. Zinterol hydrochloride increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM. Zinterol hydrochloride induces ventricular arrhythmias in conscious heart failure rabbits.	price>

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