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Catalog	name	Description	price
R-R-3858	Tamsulosin hydrochloride CAS No.106463-17-6	Tamsulosin hydrochloride ((R)-(-)-YM12617)/CAS No.106463-17-6 is an inhibitor of α1-adrenergic receptor. Tamsulosin hydrochloride is used for the research of prostatic hyperplasia. Tamsulosin hydrochloride attenuates abdominal aortic aneurysm growth in animal models.	price>
R-C-2159	E3330 CAS:136164-66-4	E3330(APX-3330)is a direct,orally active and selective AP endonuclease 1(APE1; REF-1)inhibitor,which suppresses NF-κB DNA-binding activity.E3330(APX-3330) blocks TNF-α-induced activation of IL-8 production in liver cancer cell lines. E3330(APX-3330)shows anticancer properties,such as inhibition of cancer cell growth and migration.	price>
R-R-3859	Medroxalol CAS No.56290-94-9	Medroxalol (RMI81968)/CAS No.56290-94-9 is an orally active adrenergic receptor antagonist, blocks α- and β-adrenergic receptors. Medroxalol shows antihypertensive and vasodilating effects.	price>
R-C-2160	Withaferin A CAS:5119-48-2	Withaferin A is a steroidal lactone present in W.somnifera that at 2-25μM has been shown to bind to and induce aggregation of vimentin intermediate filaments in cultured endothelial cells and fibroblasts,causing apoptosis.	price>
R-R-3860	Bupranolol CAS No.14556-46-8	Bupranolol/CAS No.14556-46-8 is an orally active, competitive and non-selective β-adrenoceptor antagonist without intrinsic sympathomimetic activity.	price>
R-C-2161	AZD7648 CAS:2230820-11-6	AZD7648 is a potent inhibitor of DNA-PK with an IC50 of 0.6nM in biochemical assay and more than 100-fold selective against 396 other kinases.	price>
R-R-3861	BMS-466442 CAS No.1598424-76-0	BMS-466442/CAS No.1598424-76-0 is a potent and selective inhibitor of asc-1 (alanine serine cysteine transporter-1), with an IC50 of 11 nM. BMS-466442 inhibits [3H] D-serine uptake into rat brain synaptosomes, with an IC50 of 400 nM. BMS-466442 can be used for schizophrenia research.	price>
R-C-2162	AZD1480 CAS:935666-88-9	AZD1480 is an orally bioavailable inhibitor of Janus-associated kinase 2(JAK2)with potential antineoplastic activity.JAK2 inhibitor AZD1480 inhibits JAK2 activation,leading to the inhibition of the JAK/STAT(signal transducer and activator of transcription)signaling including activation of STAT3.	price>
R-R-3862	Desglymidodrine CAS No.3600-87-1	Desglymidodrine (ST 1059)/CAS No.3600-87-1, the active metabolite of Midodrine (HY-12749), is a selective α1-adrenoceptor agonist. Desglymidodrine is an effective arterial and venous vasoconstrictor and can be used to regulate blood pressure.	price>
R-C-2163	Linderalactone CAS:728-61-0	Linderalactone inhibits human lung cancer growth by modulating the expression of apoptosis-related proteins(Bax and Bcl-2)with an IC50 of 15µM in A-549 cells. Linderalactone induces G2/M cell cycle arrest and could also suppress the JAK/STAT signalling pathway.	price>
R-R-3863	Metipranolol hydrochloride CAS No.36592-77-5	Metipranolol hydrochloride/CAS No.36592-77-5 is a non-selective β adrenergic receptor blocking agent.	price>
R-C-2164	PF-06826647 CAS:2127109-84-4	PF-06826647 is an orally active and selective TYK2 inhibitor(IC50=17nM),which binds to TYK2 catalytically active JH1 domain.PF-06826647 displays selectivity for TYK2 over JAK1(IC50=383nM)and JAK2(74nM).PF-06826647 can be used for the research of psoriasis,ulcerative colitis, and hidradenitis suppurativa.	price>
R-R-3864	Dicentrine CAS No.517-66-8	Dicentrine/CAS No.517-66-8 is a natural product isolated from the plant Stephania epigaea Lo with antihypertensive effect. Dicentrine is an α1-adrenoceptor antagonist which has effective against human hyperplastic prostates.	price>
R-C-2165	TG101209 CAS:936091-14-4	TG101209 is a selective JAK2 inhibitor with IC50 of 6nM, less potent to Flt3 and RET(c-RET)with IC50 of 25 nM and 17nM in cell-free assays,~30-fold selective for JAK2 than JAK3, sensitive to JAK2V617F and MPLW515L/K mutations.	price>
R-R-3865	HOKU-81 CAS No.58020-43-2	HOKU-81 (4-Hydroxytulobuterol)/CAS No.58020-43-2 is one of the metabolites of Tulobuterol (HY-B1810). HOKU-81 is a potent and selective β2-adrenoceptor stimulant. HOKU-81 has bronchodilating effect.	price>
R-C-2166	Upadacitinib (ABT-494) CAS:1310726-60-3	Upadacitinib（ABT-494)is a potent and selective JAK inhibitors in development for rheumatoid arthritis.ABT-494 is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific,relevant cytokines.ABT-494 demonstrates efficacy in rat arthritis models.	price>
R-R-3866	(S)-Carvedilol CAS No.95094-00-1	(S)-Carvedilol/CAS No.95094-00-1, the S-enantiomer of Carvedilol, is a non-selective β/α-1 blocker. (S)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).	price>
R-C-2167	Abrocitinib (PF-04965842) CAS:1622902-68-4	Abrocitinib(PF-04965842)is a potent,orally active and selective JAK1 inhibitor, with IC50s of 29 and 803nM for JAK1 and JAK2,respectively.Abrocitinib(PF-04965842)exhibits less active effect on TYK2(IC50,1.253μM),and inhibits phosphorylation of STAT1,STAT3 and STAT5 after stimulation.Effective in autoimmune disease.	price>
R-R-3867	FFN270 hydrochloride CAS No.2341841-05-0	FFN270 hydrochloride/CAS No.2341841-05-0, a fluorescent tracer of norepinephrine, is a fluorescent substrate of the norepinephrine and vesicular monoamine transporters. FFN270 hydrochloride exhibits two resolved absorption/excitation maxima depending on solvent pH (FFN270 ex: 320 nm or 365 nm, em: 475 nm) and can function as ratiometric fluorescent pH-sensors.	price>
R-C-2168	Itacitinib (INCB39110) CAS:1334298-90-6	INCB39110 is a potent JAK1 tyrosine kinase inhibitor,which is currently in Phase II trials for the treatment of rheumatoid arthritis,myelofibrosis,rheumatoid arthritis and plaque psoriasis.	price>

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