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Catalog	name	Description	price
R-C-2276	Gemcitabine (LY-188011) CAS:95058-81-4	Gemcitabine(LY 188011)is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent.Gemcitabine inhibits DNA synthesis and repair,resulting in autophagyand apoptosis.	price>
R-R-3976	Isoxsuprine-d6 hydrochloride CAS No.2706004-35-3	Isoxsuprine-d6 (hydrochloride)/CAS No.2706004-35-3 is the deuterium labeled Isoxsuprine hydrochloride. Isoxsuprine hydrochloride is a beta-adrenergic receptor agonist with Kis of 13.65 μΜ and 3.48 μΜ for myometrial and placcntal beta-adrenergic receptor, respectively. Isoxsuprine hydrochloride is also a NMDA receptor antagonist.	price>
R-C-2277	Nelarabine CAS:121032-29-9	Nelarabine(Arranon,506U78)is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15μM in tumor cells.	price>
R-R-3977	Azepexole dihydrochloride CAS No.36067-72-8	Azepexole (B-HT 933) dihydrochloride/CAS No.36067-72-8 is a potent and selective alpha 2-adrenoceptor agonist with pKis of 8.3, 7.6, and 7.5 for α2A-, α2B- and α2C-adrenoceptor subtypes, resepctively. Azepexole dihydrochloride causes concentration-dependent inhibition of peristaltic contractions (IC50= 78.72 nM).	price>
R-C-2278	Cladribine (RWJ 26251) CAS:4291-63-8	Cladribine(RWJ 26251,Leustatin,2-CdA,2-chlorodeoxyadenosine,2-Chloro-2-deoxyadenosine,CldAdo,Jk 6251,NSC 105014)is an adenosine deaminase inhibitor for U266,RPMI8226,and MM1.S cells with IC50 of approximately 2.43μM,0.75μM,and 0.18μM,respectively.	price>
R-R-3978	Betaxolol-d7 hydrochloride CAS No.1219802-92-2	Betaxolol-d7 (hydrochloride)/CAS No.1219802-92-2 is the deuterium labeled Betaxolol hydrochloride. Betaxolol Hydrochloride is a selective beta1 adrenergic receptor blocker that can be used for the research of hypertension and glaucoma.	price>
R-C-2279	Raltitrexed CAS:112887-68-0	Raltitrexed(Tomudex)is an inhibitor of thymidylate synthase and also is one of the strongest antimetabolites in use.	price>
R-R-3979	Cimbuterol CAS No.54239-39-3	Cimbuterol/CAS No.54239-39-3 is a β-adrenergic receptor agonist.	price>
R-C-2280	Clofarabine CAS:123318-82-1	Clofarabine is a second generation purine nucleoside analog with antineoplastic activity.Clofarabine is phosphorylated intracellularly to the cytotoxic active 5-triphosphate metabolite,which inhibits the enzymatic activities of ribonucleotide reductase and DNA polymerase,resulting in inhibition of DNA repair and synthesis of DNA and RNA.This nucleoside analog also disrupts mitochondrial function and membrane integrity,resulting in the release of pre-apoptotic factors,including cytochrome C and apoptotic-inducing factor,which activate apoptosis.	price>
R-R-3980	Tizanidine-d4 hydrochloride CAS No.1188263-51-5	Tizanidine-d4 (hydrochloride)/CAS No.1188263-51-5 is deuterium labeled Tizanidine (hydrochloride).	price>
R-C-2281	Go6976 CAS:136194-77-9	Go6976 is a potent PKC inhibitor with IC50 of 7.9nM,2.3nM,and 6.2nM for PKC(Rat brain),PKCα,and PKCβ1,respectively.Also a potent inhibitor of JAK2 and Flt3.	price>
R-R-3981	Guanfacine-13C,15N3 CAS No.1189924-28-4	Guanfacine-13C,15N3/CAS No.1189924-28-4 is the 13C and 15N labeled Guanfacine. Guanfacine is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation.	price>
R-C-2282	Pomalidomide (CC-4047) CAS:19171-19-8	Pomalidomide,the third-generation immunomodulatory agent,acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors.	price>
R-R-3982	Talibegron hydrochloride CAS No.178600-17-4	Talibegron hydrochloride (ZD2079 hydrochloride)/CAS No.178600-17-4 is a potent β3-adrenoceptor agonist with a pD2 of 3.72 on phenylephrine-preconstricted rat mesenteric artery. Talibegron hydrochloride has potent vasorelaxant effect.	price>
R-C-2283	CC-90009 CAS:1860875-51-9	CC-90009 is a cereblon modulator.CC-90009 specifically binds to CRBN,thereby affecting the activity of the ubiquitin E3 ligase complex.This leads to the ubiquitination of certain substrate proteins and induces the proteasome-mediated degradation of certain transcription factors,including Ikaros(IKZF1)and Aiolos (IKZF3),which are transcriptional repressors in T-cells.This reduces the levels of these transcription factors,and modulates the activity of the immune system, which may include the activation of T-lymphocytes.	price>
R-R-3983	Perphenazine-d8 dihydrochloride CAS No.2070015-23-3	Perphenazine-d8 (dihydrochloride)/CAS No.2070015-23-3 is the deuterium labeled Perphenazine, which is a typical antipsychotic agent(5-HT, Dopamine receptor ligand).	price>
R-C-2284	SZL P1-41 CAS: 222716-34-9	SZL P1-41(compound #25)is a specific inhibitor of S-phase kinase-associated protein 2(Skp2)that indeed binds to Skp2,prevents Skp2-Skp1 interaction and inhibits Skp2 SCF E3 ligase activity,which consequently suppresses survival of cancer cells and cancer stem cells.SZL P1-41 causes higher apoptosis rates in cancer cells.	price>
R-R-3984	Phentolamine-d4 hydrochloride CAS No.1346599-65-2	Phentolamine-d4 (hydrochloride)/CAS No.1346599-65-2 is the deuterium labeled Phentolamine hydrochloride. Phentolamine hydrochloride is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine hydrochloride can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction.	price>
R-C-2285	Xevinapant (AT406) CAS:1071992-99-8	Xevinapant(AT406,ARRY-334543,Debio1143,SM-406)is a potent Smac mimetic and an antagonist of IAP(inhibitor of apoptosis protein via E3 ubiquitin ligase),binding to XIAP-BIR3,cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4nM,1.9 nM,and 5.1nM,50-to 100-fold higher affinities than the Smac AVPI peptide.	price>
R-R-3985	Silodosin-d4 CAS No.1426173-86-5	Silodosin-d4/CAS No.1426173-86-5 is the deuterium labeled Silodosin. Silodosin (KAD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (Ki=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with Ki values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH.	price>

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