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Catalog	name	Description	price
R-C-2476	Diphemanil Methylsulfate CAS:62-97-5	Diphemanil Methylsulfate is a quaternary ammonium anticholinergic,it binds muscarinic acetycholine receptors(mAchR).	price>
R-R-4176	CCR7 Ligand 1 CAS No.681514-83-0	CCR7 Ligand 1 (CCR7-Cmp2105)/CAS No.681514-83-0 is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM.	price>
R-C-2477	Glycopyrrolate CAS:596-51-0	Glycopyrrolate(Glycopyrronium,Robinul,Gastrodyn)is a muscarinic antagonist used as an antispasmodic,in some disorders of the gastrointestinal tract,and to reduce salivation with some anesthetics.	price>
R-R-4177	BI-6901 CAS No.2040401-92-9	BI 6901/CAS No.2040401-92-9 is a potent, selective CCR10 antagonist (pIC50=9.0). BI 6901 shows high selectivity over other GPCRs, including a number of other chemokine receptors. BI 6901 is efficacious in the murine DNFB model of contact hypersensitivity and can be used for inflammation research.	price>
R-C-2478	Tropisetron CAS: 89565-68-4	Tropisetron(SDZ-ICS-930 free base)is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1±0.9nM for 5-HT3 receptor.	price>
R-R-4178	INCB 3284 CAS No.887401-92-5	INCB 3284/CAS No.887401-92-5 is a potent, selective and orally bioavailable human CCR2 antagonist, inhibiting monocyte chemoattractant protein-1 binding to hCCR2, with an IC50 of 3.7 nM. INCB 3284 can be used in the research of acute liver failure.	price>
R-C-2479	Thonzylamine CAS:91-85-0	Thonzylamine is an orally active H1 histamine receptor antagonist,exhibits good antihistaminic and antianaphylactic properties.Thonzylamine can be used for the research of hypersensitivity diseases,nasal congestion,allergic conjunctivitis and other allergic diseases.	price>
R-R-4179	MK-0812 Succinate CAS No.851916-42-2	MK-0812 Succinate/CAS No.851916-42-2 is a potent and selective CCR2 antagonist with high affinity at CCR2.	price>
R-C-2480	Caulophylline (N-Methylcytisine) CAS:486-86-2	Caulophylline(N-Methylcytisine,Caulophyllin,NMC)is a tricyclic quinolizidine alkaloid with anti-inflammatory activities.Caulophylline binds to nicotinic acetylcholine receptors(nAChR)from squid optical ganglia with Kd of 50nM. Caulophylline significantly reduces myeloperoxidase(MPO)activity,blocks the activation of NF-κB by inhibiting IκB and IKK phosphorylation.	price>
R-R-4180	SB-328437 CAS No.247580-43-4	SB-328437/CAS No.247580-43-4 is a potent, selective non-peptide CCR3 antagonist with an IC50 of 4.5 nM.	price>
R-C-2481	Merafloxacin CAS:91188-00-0	Merafloxacin(CI 934)is a fluoroquinolone antibacterial,which was also identified as a−1 PRF inhibitor of SARS-CoV-2.Frameshift inhibition by merafloxacin is robust to mutations within the pseudoknot region and is similarly effective on −1 PRF of other beta coronaviruses.	price>
R-R-4181	ML604086 CAS No.850330-18-6	ML604086/CAS No.850330-18-6 is a selective CCR8 inhibitor, inhibiting CCL1 binding to CCR8 on circulating T-cells. ML604086 inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations.	price>
R-C-2482	Hypocrellin A CAS:77029-83-5	Hypocrellin A(HA)is a perylenequinone isolated from Shiraia bambusicola that shows antiviral,antimicrobial and anticancer activity through mediating multiple signaling pathways.Hypocrellin A also is a selective and potent inhibitor of PKC.	price>
R-R-4182	ALK4290 CAS No.1251528-23-0	ALK4290 (AKST4290)/CAS No.1251528-23-0 is a potent and orally active CCR3 inhibitor extracted from patent US20130261153A1, compound Example 2, with a Ki of 3.2 nM for hCCR3. ALK4290 can be used for the research of neovascular age-related macular degeneration and Parkinsonism.	price>
R-C-2483	AMG-208 CAS:1002304-34-8	AMG 208 is a selective small-molecule inhibitor of the proto-oncogene c-Met with potential antineoplastic activity.c-Met inhibitor AMG 208 inhibits the ligand-dependent and ligand-independent activation of c-Met,inhibiting its tyrosine kinase activity,which may result in cell growth inhibition in tumors that overexpress c-Met.	price>
R-R-4183	PF-07054894 CAS No.2413693-96-4	PF-07054894/CAS No.2413693-96-4 is a potent CCR6 antagonist. PF-07054894 targets G protein-coupled receptor (GPCR). PF-07054894 can be used in research of inflammatory bowel disease.	price>
R-C-2484	AZ-628 CAS:878739-06-1	AZ-628 is a selective,orally available Raf inhibitor with excellent pharmacokinetic properties and robust tumor growth inhibition in xenograft studies((IC50 values are 29,34 and 105 nM for c-Raf1,B-RafV600E and wild-type B-Raf,respectively).AZ-628 inhibits growth,and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation.	price>
R-R-4184	BMS CCR2 22 CAS No.445479-97-0	BMS CCR2 22/CAS No.445479-97-0 is a potent, specific and high affinity CC-type chemokine receptor 2 (CCR2) antagonist with excellent binding affinity (binding IC50 of 5.1 nM) and potent functional antagonism (calcium flux IC50 of 18 nM and chemotaxis IC50 of 1 nM).	price>
R-C-2485	AZD-8330 CAS:869357-68-6	AZD8330(ARRY704 and ARRY424704)is an orally active,selective MEK inhibitor with potential antineoplastic activity.MEK inhibitor AZD8330 specifically inhibits mitogen-activated protein kinase kinase 1(MEK or MAP/ERK kinase1),resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation.	price>
R-R-4185	CCR2 antagonist 1 CAS No.1683534-96-4	CCR2 antagonist 1/CAS No.1683534-96-4 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM.	price>

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