Xi'an ruixi Biological Technology Co

Home > Keywords >

Catalog	name	Description	price
R-R-4206	Vercirnon sodium CAS No.886214-18-2	Vercirnon (GSK1605786A) sodium/CAS No.886214-18-2 is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon sodium inhibits CCR9-mediated Ca2+ mobilization and chemotaxis on Molt-4 cells with IC50 values of 5.4 and 3.4 nM, respectively. Vercirnon sodium is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s>10 µM for all). Vercirnon sodium is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC50 values of 2.8 and 2.6 nM, respectively.	price>
R-R-4207	CCR4 antagonist 4 CAS No.668980-17-4	CCR4 antagonist 4 (compound 22)/CAS No.668980-17-4 is a selective and potent antagonist of the CC chemokine receptor-4 (CCR4), with an IC50 of 0.02 μM. CCR4 antagonist 4 also blocks MDC-mediated chemotaxis (IC50: 0.007 μM) and Ca2+ mobilization (IC50: 0.003 μM). CCR4 antagonist 4 can be used for allergic inflammation research.	price>
R-C-2508	PF-5274857 CAS:1373615-35-0	PF-5274857 is a potent,selective,orally active and brain-penetrant antagonist of Smo,with an IC50 of 5.8nM and Ki of 4.6nM. PF-5274857 has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.	price>
R-R-4208	Nifeviroc CAS No.934740-33-7	Nifeviroc/CAS No.934740-33-7 is an orally active CCR5 antagonist. Nifeviroc is used for the study of HIV type-1 infection.	price>
R-C-2509	Bikinin(Abrasin) CAS:188011-69-0	Bikinin is a non-steroidal,ATP-competitive inhibitor of plant GSK-3/Shaggy-like kinases and activates BR(brassinosteroids)signaling.	price>
R-R-4209	CCR2 antagonist 4 CAS No.226226-39-7	CCR2 antagonist 4 (Teijin compound 1)/CAS No.226226-39-7 is a potent and specific CCR2 antagonist, with IC50s of 180 nM for CCR2b. CCR2 antagonist 4 potently inhibits MCP-1-induced chemotaxis with an IC50 of 24 nM.	price>
R-C-2510	AKT inhibitor IV CAS:959841-49-7	AKT Inhibitor IV promotes hyperphosphorylation of Akt(Protein kinase B), decreases phosphorylation of Akt substrates,and inhibits FOXO1a nuclear export (IC50=625nM in PTEN-null cells).AKT Inhibitor IV inhibits the proliferation of several cells lines(IC50 values are <1.25μM,320-670nM and 340nM for 786-O, HeLa and Jurkat cells,respectively).This compound also displays broad antiviral activity against negative-stranded RNA viruses.	price>
R-R-4210	Aplaviroc hydrochloride CAS No.461023-63-2	Aplaviroc (AK 602) hydrochloride/CAS No.461023-63-2, a SDP derivative, is a CCR5 antagonist, with IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.	price>
R-C-2511	MDL28170 CAS:88191-84-8	MDL-28170(Calpain Inhibitor III)is a potent and selective calpain inhibitor of calpain that penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration.MDL-28170 is also an inhibitor of γ-secretase.	price>
R-R-4211	AZD-1678 CAS No.942137-41-9	AZD-1678/CAS No.942137-41-9 is a potent CCR4 receptor antagonist, with a pIC50 of 8.6.	price>
R-C-2512	LCZ696(Sacubitril;Valsartan) CAS:936623-90-4	Sacubitril/Valsartan(LCZ696),comprised Valsartan and Sacubitril(AHU377)in 1:1 molar ratio,is a first-in-class,orally bioavailable,and dual-acting angiotensin receptor-neprilysin(ARN)inhibitor for hypertension and heart failure. Sacubitril/Valsartan ameliorates diabetic cardiomyopathy by inhibiting inflammation,oxidative stress and apoptosis.	price>
R-R-4212	CCR4 antagonist 3 CAS No.1957-01-3	CCR4 antagonist 3/CAS No.1957-01-3 is a potent chemokine receptor 4 (CCR4) antagonist with an IC50 value of 1.7 μM for [125I]TARC (thymus and activation regulated chemokine). CCR4 antagonist 3 inhibits binding of radiolabeled TARC and macrophage-derived chemokine (MDC) to CCR4 receptors on the surface of CEM cells. CCR4 antagonist 3 also inhibits the in vitro migration of CEM cells mediated by TARC (IC50 = 6.4 μM).	price>
R-R-4213	CCX354 CAS No.1010073-75-2	CCX354/CAS No.1010073-75-2 is an antagonist of CCR1, with anti-inflammatory activity.	price>
R-C-2514	Olprinone CAS:106730-54-5	Olprinone(Loprinone)is a potent phosphodiesterase(PDE)3 inhibitor,with IC50s of 150,100,0.35 and 14μM for PDE1,PDE2,PDE3 and PDE4,respectively.Olprinone is used for the research of heart failure due to its positive inotropic and vasodilative effects.Anti-inflammatory activity.	price>
R-R-4214	CCR4-351 hydrochloride CAS No.2174938-71-5	CCR4-351 hydrochloride/CAS No.2174938-71-5 is an orally active, potent and selective CCR4 antagonist. CCR4-351 hydrochloride, featuring a novel piperidinyl-azetidine motif, has IC50s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4-351 hydrochloride has antitumor activity.	price>
R-C-2515	Gimeracil CAS:103766-25-2	Gimeracil is a pyridine derivative with antitumor activity.Gimeracil enhances the antitumor activity of fluoropyrimidines by competitively and reversibly inhibiting the enzyme dihydropyrimidine dehydrogenase causing decreased degradation of the fluoropyrimidines.	price>
R-R-4215	INCB3344 R-isomer	INCB3344 R-isomer is the R-isomer of INCB3344. INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity.	price>
R-C-2516	Tadalafil CAS:171596-29-5	Tadalafil（IC351）is PDE5 inhibitor marketed in pill form for treating erectile dysfunction(ED)under the name Cialis,and under the name Adcirca for the treatment of pulmonary arterial hypertension.	price>
R-R-4216	BMS-817399 CAS No.1202400-18-7	BMS-817399/CAS No.1202400-18-7 is a potent, selective, and orally bioavailable CCR1 antagonist. BMS-817399 exhibits CCR1 binding affinity and chemotaxis inhibition potencies of 1 and 6 nM (IC50), respectively. BMS-817399 can be used for the research of rheumatoid arthritis.	price>
R-C-2517	NSC14613(PluriSln1) CAS:91396-88-2	PluriSln-1(NSC 14613)is pluripotent cell-specific inhibitor(PluriSIn).PluriSIn #1 induces ER stress,protein synthesis attenuation,and apoptosis in hPSCs. PluriSIn #1 was also cytotoxic to mouse blastocysts,indicating that the dependence on oleate is inherent to the pluripotent state.The use of human pluripotent stem cells(hPSCs)in cell therapy is hindered by the tumorigenic risk from residual undifferentiated cells.	price>

633634635636637638 639640641642643