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Catalog	name	Description	price
R-R-4217	CCR3 antagonist 1 CAS No.879399-82-3	CCR3 antagonist 1/CAS No.879399-82-3 is a potent antagonist of CCR3, used for the research of immunologic and inflammatory diseases.	price>
R-C-2518	AGI-6780 CAS:1432660-47-3	AGI-6780 is a potent and selective IDH2 inhibitor.AGI-6780 inhibits the tumor-associated mutant IDH2/R140Q.Treatment with AGI-6780 induced differentiation of TF-1 erythroleukemia and primary human acute myelogenous leukemia cells in vitro.	price>
R-R-4218	Maraviroc-d6 CAS No.1033699-22-7	Maraviroc-d6 (UK-427857-d6)/CAS No.1033699-22-7 is the deuterium labeled Maraviroc. Maraviroc (UK-427857) is a selective CCR5 antagonist with activity against human HIV.	price>
R-C-2519	Dimethyloxaloylglycine;DMOG CAS:89464-63-1	DMOG(Dimethyloxallyl Glycine)is a cell permeable and competitive inhibitor of HIF-PH,which results in HIF-1α stabilisation and accmulation in vitro and in vivo.DMOG is an α-ketoglutarate analogue and inhibits α-KG-dependent hydroxylases.DMOG acts as a pro-angiogenic agent and plays a protective role in experimental model of colitis and diarrhoea via HIF-1 related signal.DMOG induces cell autophagy.	price>
R-R-4219	CKLF1-C27 CAS No.891861-48-6	CKLF1-C27/CAS No.891861-48-6, a C-terminal peptide of CKLF1, binds to CCR4 receptor and activates ERK1/2 pathway. CKLF1-C27 can abrogate the effect of CKLF1 on cells by competing for CCR4 receptor. CKLF1-C27 shows great effect on promoting proliferation on HUVECs. CKLF1-C27 has the potential for psoriasis research.	price>
R-C-2520	Moclobemide CAS:71320-77-9	Moclobemide(Ro111163)is a brain-penetrant and reversible monoamine oxidase(MAO-A)inhibitor with an IC50 of 6.061μM for hMAO-A.Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.	price>
R-R-4220	α-NETA CAS No.115066-04-1	α-NETA/CAS No.115066-04-1 is a potent and noncompetitive choline acetyltransferase (ChA) inhibitor with an IC50 of 9 μM. α-NETA is a potent ALDH1A1 (IC50=0.04 µM) and chemokine-like receptor-1 (CMKLR1) antagonist. α-NETA weakly inhibits cholinesterase (ChE; IC50=84 µM) and acetylcholinesterase (AChE; IC50=300 µM). α-NETA has anti-cancer activity.	price>
R-C-2521	Rosiglitazone CAS:155141-29-0	Rosiglitazone maleate(BRL 49653),a member of the thiazolidinedione class of antihyperglycaemic agents,is a high-affinity selective agonist of the peroxisome proliferator-activated receptor-γ(PPAR-γ)with IC50 of 42nM.	price>
R-R-4221	Devazepide CAS No.103420-77-5	Devazepide (L-364,718)/CAS No.103420-77-5 is a potent, competitive, selective and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor, with IC50s of 81 pM, 45 pM and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respectively. Devazepide (L-364,718) is effective for gastrointestinal disorders.	price>
R-C-2522	PF3845 CAS:1196109-52-0	PF-3845 is a fatty acid amide hydrolase(FAAH)inhibitor,and acts in the nervous system to reverse LPS-induced tactile allodynia in mice.PF-3845 promotes neuronal survival,attenuates inflammation and improves functional recovery in mice with traumatic brain injury.	price>
R-R-4222	Sograzepide CAS No.155488-25-8	Sograzepide (Netazepide; YF 476; YM-220)/CAS No.155488-25-8 is an extremely potent , highly selective and orally active Gastrin/CCK-B antagonist with an IC50 value of 0.1 nM, has inhibitory effect on Gastrin/CCK-A activity with an IC50 of 502 nM. Sograzepide (Netazepide; YF 476; YM-220) replaces the specific binding of [125I]CCK-8 to the rat brain, cloned canine and cloned human Gastrin/CCK-B receptors, with Ki values of 0.068, 0.62 and 0.19 nM, respectively.	price>
R-C-2523	Tezacaftor (VX-661) CAS:1152311-62-0	Tezacaftor（VX-661）is CFTR modulator.VX-661 is potentially useful for treatment of cystic fibrosis disease.Cystic fibrosis(CF)is a genetic disease caused by defects in the CF transmembrane regulator(CFTR)gene,which encodes an epithelial chloride channel.	price>
R-R-4223	L-365260 CAS No.118101-09-0	L-365260/CAS No.118101-09-0 is an orally active and selective antagonist of non-peptide gastrin and brain cholecystokinin receptor (CCK-B), with Kis of 1.9 nM and 2.0 nM, respectively. L-365260 interacts in a stereoselective and competitive manner with guinea pig stomach gastrin and brain CCK receptors. L-365260 can enhance Morphine analgesia and prevents Morphine tolerance.	price>
R-C-2524	SB705498 CAS：501951-42-4	SB-705498 is a potent,selective and orally bioavailable transient receptor potential vanilloid 1(TRPV1)receptor antagonist with a pIC50 of 7.1.	price>
R-R-4224	Proglumide sodium CAS No.99247-33-3	Proglumide sodium/CAS No.99247-33-3 is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. Proglumide sodium has ability to inhibit gastric secretion and to protect the gastroduodenal mucosa. Proglumide sodium also has antiepileptic and antioxidant activities.	price>
R-C-2525	GlyH101 CAS：328541-79-3	GlyH-101 is a CFTR inhibitor(cystic fibrosis transmembrane conductance regulator).GlyH-101 is a glycine hydrazide that has been shown to block CFTR channels.GlyH-101 blocks the open pore of cardiac CFTR channels at an electrical distance of 0.15 Â±0.03 from the external membrane surface.	price>
R-R-4225	Proglumide CAS No.6620-60-6	Proglumide/CAS No.6620-60-6 is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. Proglumide selective blocks CCK’s effects in the central nervous system (CNS). Proglumide has ability to inhibit gastric secretion and to protect the gastroduodenal mucosa. Proglumide also has antiepileptic and antioxidant activities.	price>
R-C-2526	Ataluren (PTC124) CAS：775304-57-9	Ataluren(PTC124)selectively induces ribosomal read-through of premature but not normal termination codons,with EC50 of 0.1μM in HEK293 cells,may provide treatment for genetic disorders caused by nonsense mutations.	price>
R-R-4226	SR 146131 CAS No.221671-61-0	SR 146131/CAS No.221671-61-0 is a potent, orally available, and selective nonpeptide (cholecystokinin 1) receptor agonist.	price>
R-C-2527	Vinpocetine CAS：42971-09-5	Vinpocetine(Ethyl apovincaminate)is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels.The IC50 value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17μM.Vinpocetine is a phosphodiesterase(PDE)inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex(IKK).	price>

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