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Catalog	name	Description	price
R-R-4251	PS372424 hydrochloride CAS No.1596362-29-6	PS372424 hydrochloride/CAS No.1596362-29-6, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 hydrochloride prevents human T-cell migration in a humanized model of arthritic inflammation.	price>
R-C-2552	AZD7762 CAS:860352-01-8	AZD-7762 is a synthetic small molecule inhibitor of checkpoint kinases(Chks)with potential chemosensitizing activity.AZD7762 binds to and inhibits Chks,which may prevent cell cycle arrest and subsequent nucleotide excision repair in DNA-damaged tumor cells,resulting in tumor cell apoptosis.This agent may enhance the cytotoxicity of DNA-damaging agents.Chks are protein kinases that regulate either G1/S or G2/M transitions in the cell cycle. In the presence of DNA damage or incomplete DNA replication,Chks become activated and initiate cell cycle arrest to allow DNA repair or the completion of DNA replication.	price>
R-R-4252	Reparixin L-lysine salt CAS No.266359-93-7	Reparixin L-lysine salt/CAS No.266359-93-7 is an allosteric inhibitor of chemokine receptor 1/2 (CXCR1/2) activation.	price>
R-C-2553	RO3280 CAS:1062243-51-9	Ro3280 is a selective inhibitor of PLK1 with IC50 value of 3nM.Polo-like kinase 1 (PLK1)is an enzyme and plays an important role in regulating cell cycles as an early trigger for G2/M phase transition.	price>
R-R-4253	TC14012 CAS No.368874-34-4	TC14012/CAS No.368874-34-4, a serum-stable derivative of T140, is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM. TC14012 is a potent CXCR7 agonist with an EC50 of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 has anti-HIV activity and anti-cancer activity.	price>
R-C-2554	BI 2536 CAS:755038-02-9	BI-2563 is a small molecule compound with potential antineoplastic activities.BI 2536 binds to and inhibits Polo-like kinase 1(Plk1),resulting in mitotic arrest,disruption of cytokinesis,and apoptosis in susceptible tumor cell populations.Plk1,a serine/threonine-protein kinase,is a key regulator of multiple processes fundamental to mitosis and cell division.	price>
R-R-4254	Kynurenic acid-d5 CAS No.350820-13-2	Kynurenic acid-d5/CAS No.350820-13-2 is the deuterium labeled Kynurenic acid. Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.	price>
R-C-2555	BPR1J-097 CAS:1327167-19-0	BPR1J-097 is a novel small molecule FLT-3 inhibitor with promising in vivo anti-tumour activities.BPR1J-097 inhibited FLT3/signal transducer and activator of transcription 5 phosphorylation and triggered apoptosis in FLT3-driven AML cells.BPR1J-097 also showed favourable pharmacokinetic property and pronounced dose-dependent tumour growth inhibition and regression in FLT3-driven AML murine xenograft models.	price>
R-R-4255	Kynurenic acid sodium CAS No.2439-02-3	Kynurenic acid sodium/CAS No.2439-02-3, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid sodium is also an agonist of GPR35/CXCR8.	price>
R-C-2556	Dynasore CAS:304448-55-3	Dynasore is a cell-permeable,reversible non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2,with IC50 of 15μM in a cell-free assay,also inhibits the mitochondrial dynamin Drp1,with no effect against other small GTPase.Dynasore suppresses mTORC1 activity and induces autophagy.	price>
R-R-4256	Nicotinamide N-oxide CAS No.1986-81-8	Nicotinamide N-oxide/CAS No.1986-81-8, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor.	price>
R-C-2557	KY02111 CAS:1118807-13-8	KY02111 is a potent and selective inhibitor of Wnt.KY02111 promotes differentiation of hPSCs by inhibiting WNT signaling that is distinct.KY 02111 may by targeting the downstream from GSK3βand APC in β-catenin destruction complex.	price>
R-R-4257	Burixafor hydrobromide CAS No.1191450-19-7	Burixafor hydrobromide (TG-0054 hydrobromide)/CAS No.1191450-19-7 is an orally bioavailable and potent antagonist of CXCR4 and a well anti-angiogenic drug that is of potential value in treating choroid neovascularization. Burixafor hydrobromide (TG-0054 hydrobromide) mobilizes mesenchymal stem cells, attenuates inflammation, and preserves cardiac systolic function in a porcine model of myocardial infarction.	price>
R-C-2558	BML-284 CAS:853220-52-7	BML-284 is a potent and cell-permeable Wnt signaling activator.BML-284 induces TCF-dependent transcriptional activity with an EC50 of 700nM.	price>
R-R-4258	FC131 TFA CAS No.842166-42-1	FC131 TFA/CAS No.842166-42-1 is a CXCR4 antagonist, inhibits [125I]-SDF-1 binding to CXCR4, with an IC50 of 4.5 nM. Anti-HIV activity.	price>
R-C-2559	CK636 CAS:442632-72-6	CK-636 is a cell permeable inhibitor of Arp2/3 complex,that could inhibit actin polymerization,with IC50 values of 4μM,24μM and 32μM for human,fission yeast and bovine,respectively.	price>
R-R-4259	Elubrixin tosylate CAS No.960495-43-6	Elubrixin tosylate (SB-656933 tosylate)/CAS No.960495-43-6 is a potent, selective, competitive, reversible and orally active CXCR2 antagonist and an IL-8 receptor antagonist. Elubrixin tosylate inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin tosylate has the potential for inflammatory diseases research, such as inflammatory bowel disease and airway inflammation.	price>
R-C-2560	PD318088 CAS：391210-00-7	PD318088 is a potent,allosteric and non-ATP competitive MEK1/2 inhibitor,an analog of PD184352(HY-50295).PD318088 binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.	price>
R-R-4260	CXCR2-IN-1 CAS No.1873376-49-8	CXCR2-IN-1/CAS No.1873376-49-8 is a central nervous system penetrant CXCR2 antagonist with a pIC50 of 9.3.	price>
R-C-2561	GDC-0879 (AR-00341677) CAS：905281-76-7	GDC-0879(AR-00341677)is a novel,potent,and selective B-Raf inhibitor with IC50 of 0.13nM in A375 and Colo205 cells with activity against c-Raf as well;no inhibition known to other protein kinases.	price>

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