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Catalog	name	Description	price
R-C-2573	Delanzomib (CEP-18770) CAS:847499-27-8	Delanzomib(CEP-18770)is a potent and orally active chymotrypsin-like activity of the proteasome inhibitor with an IC50 of 3.8nM.Delanzomib inhibits NF-κB activity,induces cancer cell apoptotic,and has strong antiangiogenic and anti-cancer activities.	price>
R-R-4273	ACT-777991 CAS No.1967811-46-6	ACT-777991/CAS No.1967811-46-6 is an orally active and selective CXCR3 antagonist. ACT-777991 has microsomes and hepatocytes stability across animal models. ACT-777991 inhibits the migration of activated T cells toward CXCL11.	price>
R-C-2574	Trabectedin CAS:114899-77-3	Trabectedin(Ecteinascidin 743;ET-743)is a tetrahydroisoquinoline alkaloid with potent antitumor activity.Trabectedin binds to the minor groove of DNA,blocks transcription of stress-induced proteins,induces DNA backbone cleavage and cancer cells apoptosis,and increases the generation of ROS in MCF-7 and MDA-MB-453 cells.	price>
R-R-4274	CXCR7 modulator 1 CAS No.2231812-31-8	CXCR7 modulator 1 (compound 25)/CAS No.2231812-31-8 is a potent and orally bioavailable peptoid hybrid CXCR7 modulator, with a Ki of 9 nM.	price>
R-C-2575	Sabutoclax CAS:1228108-65-3	Sabutoclax(BI-97C1)is a potent a Mcl-1 Antagonist.Sabutoclax inhibits Tumorigenesis in Transgenic Mouse and Human Xenograft Models of Prostate Cancer. Sabutoclax(BI97C1)induce mitochondrial fragmentation either upstream of or independent of apoptosis.	price>
R-R-4275	(R,R)-CXCR2-IN-2 CAS No.1838123-22-0	(R,R)-CXCR2-IN-2/CAS No.1838123-22-0, diastereoisomer of CXCR2-IN-2 (compound 68), is a brain penetrant CXCR2 antagonist with a pIC50 of 9 and 6.8 in the Tango assay and d in the HWB Gro-α induced CD11b expression assay, respectively.	price>
R-C-2576	NVP-CGM097 CAS:1313363-54-0	NVP-CGM097 is a highly potent and selective MDM2 inhibitor with Ki value of 1.3nM for hMDM2 in TR-FRET assay.It binds to the p53 binding-site of the Mdm2 protein,disrupting the interaction between both proteins,leading to an activation of the p53 pathway.	price>
R-R-4276	MSX-127 CAS No.6616-56-4	MSX-127/CAS No.6616-56-4 is a CXCR4 antagonist. MSX-127 inhibits cancer metastasis.	price>
R-C-2577	Navtemadlin (AMG 232) CAS:1352066-68-2	Navtemadlin(AMG 232)is a potent,selective and orally available inhibitor of p53-MDM2 interaction,with an IC50 of 0.6nM.Navtemadlin binds to MDM2 with a Kd of 0.045nM.	price>
R-R-4277	MSX-130 CAS No.4051-59-6	MSX-130/CAS No.4051-59-6 is a CXCR4 antagonist. MSX-130 inhibits cancer metastasis.	price>
R-C-2578	Necrosulfonamide CAS:1360614-48-7	Necrosulfonamide is a novel inhibitor of MLKL(mixed lineage kinase domain-like). Necrosulfonamide is a cell-permeable inhibitor that covalently modifies Cys88 and blocks human MLKL adaptor function.	price>
R-R-4278	Vimnerixin CAS No.1418112-77-2	Vimnerixin (AZD4721)/CAS No.1418112-77-2 is the potent and orally active antagonist of acidic CXC chemokine receptor 2 (CXCR2). Vimnerixin has the potential for the research of inflammatory disease.	price>
R-C-2579	YH239-EE CAS:1364488-67-4	YH239-EE,ethyl ester of the free carboxylic acid compound YH239,is a potent p53-MDM2 antagonizing and apoptosis-inducing agent.	price>
R-R-4279	AZD8309 CAS No.333742-48-6	AZD8309 is an orally active antagonist of CXCR2. AZD8309 has the ability to regulate the transmigration of neutrophils. AZD8309 can be used in the study of inflammatory diseases.	price>
R-C-2580	BM-1074 CAS:1391108-10-3	BM-1074 is a potent Bcl-2/Bcl-xL inhibitor which is capable of achieving rapid, complete,and durable tumor regression in vivo.	price>
R-R-4280	ACT-660602 CAS No.1646267-59-5	ACT-660602/CAS No.1646267-59-5 is an orally active antagonist of chemokine receptor (CXCR3) with an IC50 value of 204 nM. ACT-660602 inhibits T-cell migration and shows efficacy in acute lung ingury model. ACT-660602 can be used for autoimmune diseases research.	price>
R-C-2581	U 73343 CAS:142878-12-4	U-73343,works as a protonophore,is an inactive analog of U-73122 and can be used as a negative control.U-73343 dose-dependently inhibits acid secretion irrespective of the stimulant.U-73122 is a phospholipase C(PLC)and 5-LO(5-lipoxygenase)inhibitor with an IC50 of 1-2.1µM for PLC.	price>
R-R-4281	SCH 563705 CAS No.473728-58-4	SCH 563705/CAS No.473728-58-4 is a potent and orally available CXCR2 and CXCR1 antagonist, with IC50s of 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively.	price>
R-C-2582	WEHI-539 CAS:1431866-33-9	WEHI-539 was designed as a BCL-XLinhibitor with high affinity.It interacted the with the binding groove of BCL-XLwith a Kd value of 0.6nM.In MEF cells lacking MCL-1,WEHI-539 induced apoptosis which was evidenced by the release of mitochondrial cytochrome cand caspase-3 processing.	price>
R-R-4282	CTCE-0214 CAS No.577782-52-6	CTCE-0214/CAS No.577782-52-6 is a chemokine CXC receptor 4 (CXCR4) agonist, SDF-1α (stromal cell-derived factor-1α) peptide analog. CTCE-0214 shows anti-inflammatory activity, and can be used in inflammation sepsis and systemic inflammatory syndromes research.	price>

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