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Catalog	name	Description	price
R-R-4438	ATR-IN-4 CAS No.2574545-45-0	ATR-IN-4/CAS No.2574545-45-0 is a potent ATR (Ataxia telangiectasia mutated gene Rad 3-associated kinase) inhibitor. ATR-IN-4 inhibits growth of human prostate cancer cells DU145 and human lung cancer cells NCI-H460 with IC50s of 130.9 nM and 41 .33 nM, respectively. (Patent CN112142744A, compound 13).	price>
R-C-2739	PF-04620110 CAS:1109276-89-2	PF-04620110 is a potent,selective and orally bioavailable diglyceride acyltransferase-1(DGAT-1)inhibitor with an IC50 of 19nM.	price>
R-R-4439	Tozasertib CAS No.639089-54-6	Tozasertib (VX 680; MK-0457)/CAS No.639089-54-6 is an inhibitor of Aurora A/B/C kinases with Kis of 0.6, 18, 4.6 nM, respectively.	price>
R-C-2740	VER 155008 CAS:1134156-31-2	VER-155008 is an inhibitor of Hsp70,with IC50s of 0.5μM,2.6μM,and 2.6μM for Hsp70,Hsc70 and Grp7,respectively,and with a Kd of 0.3μM for Hsp70.	price>
R-R-4440	JAB-2485 CAS No.2899209-55-1	JAB-2485/CAS No.2899209-55-1 is a potent and selective Aurora kinase A (AURKA) inhibitor, with an IC50 of 0.33 nM. JAB-2485 exhibits around 1700-fold selectivity for AURKA over AURKB. JAB-2485 induces cell cycle arrest and apoptosis. JAB-2485 can be used for the research of cancer.	price>
R-C-2741	TAK 21d CAS:1143578-94-2	TAK-21d is a potent FAAH Inhibitor.	price>
R-R-4441	Hesperadin CAS No.422513-13-1	Hesperadin/CAS No.422513-13-1 is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin inhibits Aurora B with an IC50 of 250 nM. Hesperadin inhibits the growth of Trypanosoma brucei by blocking nuclear division and cytokinesis. Hesperadin also is a broad-spectrum influenza antiviral.	price>
R-C-2742	XL-888 CAS:1149705-71-4	XL888 is an orally bioavailable,ATP-competitive,small-molecule inhibitor of heat shock protein 90(Hsp90)with potential antineoplastic activity.	price>
R-R-4442	AMG 900 CAS No.945595-80-2	AMG 900/CAS No.945595-80-2 is a potent and highly selective pan-Aurora kinases inhibitor with IC50 of 5 nM, 4 nM and 1 nM for Aurora A, B and C, respectively.	price>
R-C-2743	AZD7687 CAS:1166827-44-6	AZD7687 is a potent,selective,reversible and orally active diacylglycerol acyltransferase 1(DGAT1)inhibitor with an IC50 of 80nM for human DGAT1. AZD7687 can be used for type 2 diabetes mellitus and obesity research.	price>
R-R-4443	ZM-447439 CAS No.331771-20-1	ZM-447439/CAS No.331771-20-1 is an aurora kinase inhibitor with IC50s of 110 and 130 nM for aurora A and B, respectively.	price>
R-C-2744	AP-III-a4 CAS:2070014-95-6	ENOblock(AP-III-a4)is a novel small molecule which is the first,nonsubstrate analogue that directly binds to enolase and inhibits its activity(IC50=0.576uM);inhibit cancer cell metastasis in vivo.	price>
R-R-4444	LY3295668 CAS No.1919888-06-4	LY3295668 (AK-01)/CAS No.1919888-06-4 is a potent, orally active and highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively.	price>
R-C-2745	nTZDpa CAS:118414-59-8	Potent,selective non-thiazolidinedione PPARγ partial agonist (EC50=57nM);produces~25% maximum efficacy.Antagonizes full agonist activity by ~60%(IC50~285nM).Displays no activity at PPARα or PPARδ receptors.	price>
R-R-4445	PF-03814735 CAS No.942487-16-3	PF-03814735/CAS No.942487-16-3 is a potent, orally available, ATP-competitive and reversible aurora A and aurora B inhibitor with IC50s of 0.8 and 0.5 nM, respectively.	price>
R-C-2746	Isosafrole CAS:120-58-1	Isosafrole,a stiripentol analog,is a potent LDH inhibitor.Stiripentol is a new-generation antiepileptic drug,and its chemical structure is unrelated to other antiepileptic drugs.Seizures and epileptiform activity are reduced by inhibition of the metabolic pathway via lactate dehydrogenase(LDH),which is a component of the astrocyte-neuron lactate shuttle.	price>
R-R-4446	MLN8054 CAS No.869363-13-3	MLN8054/CAS No.869363-13-3 is a potent, selective and orally available aurora A kinase inhibitor with an IC50 of 4 nM.	price>
R-C-2747	DASA-58 CAS:1203494-49-8	DASA-58 is a potent activator of pyruvate kinase M2(PKM2)with an AC90 of 680 nM, and an AC50 of 38nM.	price>
R-R-4447	JB170 CAS No.2705844-82-0	JB170/CAS No.2705844-82-0 is a potent and highly specific PROTAC-mediated AURORA-A (Aurora Kinase) degrader (DC50=28 nM) by linking Alisertib, to the Cereblon-binding molecule Thalidomide. JB170 preferentially binds AURORA-A (EC50=193 nM) over AURORA-B (EC50=1.4 µM). JB170-mediated S-phase arrest is caused specifically by AURORA-A depletion. JB170 has excellent ability to inhibit non-catalytic function of AURORA-A kinase.	price>
R-C-2748	PF-04971729(Ertugliflozin) CAS:1210344-57-2	Ertugliflozin(PF-04971729)is a potent,selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2(SGLT2),with an IC50 of 0.877nM for h-SGLT2.Has the potential for the treatment of type 2 diabetes mellitus.	price>

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