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R-R-4620 Zoliflodacin CAS No.1620458-09-4 Zoliflodacin (ETX0914;AZD0914)/CAS No.1620458-09-4 is a novel spiropyrimidinetrione bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus with the MIC90 of 0.25 μg/mL. price>
R-C-2951 PAMAM G3-NH2 PAMAM is a polyamide amine dendrimer with colorless to yellowish transparent liquid.As a carrier of drugs,genes and vaccines in the field of biomedicine,it is used for drug sustained-release and targeted release;it is used for in-vitro diagnosis,in vitro gene transfer,gene therapy,nuclear magnetic resonance imaging and other applications. price>
R-R-4621 116-9e CAS No.831217-43-7 116-9e (MAL2-11B)/CAS No.831217-43-7 is a Hsp70 co-chaperone DNAJA1 inhibitor. 116-9e inhibits Simian Virus 40 (SV40) replication and DNA synthesis. price>
R-C-2952 Poly-L-lysine (MW:20-40k) ε- Polylysine is polymerized from 25 ~ 30 lysine residues. It has strong antibacterial ability and can be used as a preservative for food preservation. ε- Polylysine has a wide antibacterial spectrum and has a certain antibacterial effect on Gram-positive bacteria, Gram-negative bacteria, yeasts and molds in acidic and slightly acidic environment. price>
R-R-4622 DDD85646 CAS No.1215010-55-1 DDD85646 (IMP-366)/CAS No.1215010-55-1 is an orally active of trypanosoma brucei N-myristoyltransferase (TbNMT IC50=2 nM; hNMT IC50=4 nM). The enzyme N-myristoyltransferase (NMT) is a potential agent target for human African trypanosomiasis. price>
R-C-2953 Gamma-PGA MW:20-40k Gamma PGA is a natural occurring, multi-functional, and biodegradable biopolymer. It is produced through fermentation by Bacillus subtilis using glutamic acid. PGA is consists of glutamic acid monomers crosslinked between α-amino and γ-carboxyl groups, and the molecular weight of PGA is usually between 100~1000 kDa. price>
R-R-4623 Fialuridine CAS No.69123-98-4 Fialuridine/CAS No.69123-98-4 is a nucleoside analog with antiviral activity. Fialuridine shows anti-orthopoxvirus activity. price>
R-C-2954 Oligoarginine-FITC Labeled Isothiocyanate fluorescent orange red,isothiocyanate fluorescent yellow,isothiocyanate fluorescent red, isothiocyanate fluorescein isomer I, 5-isothiocyanate fluorescein. Its form is yellow powder with hygroscopicity. It is a biochemical reagent. price>
R-R-4624 L82 CAS No.329227-30-7 L82/CAS No.329227-30-7 is a selective and uncompetitive DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM). L82 shows anti-proliferative activity to breast cancer cells price>
R-C-2955 Oligoarginine-TAMRA Labeled RuixiBiotechCo.Ltd sells research regeats related to nano targeted drug delivery system, including synthetic phospholipid, polyethylene glycol derivatives, block copolymers, gold nanoparticles, magnetic nanoparticles and fluorescent dyes. price>
R-R-4625 COH29 CAS No.1190932-38-7 COH29 (RNR Inhibitor COH29)/CAS No.1190932-38-7 is a potent ribonucleotide reductase (RNR) inhibitor with anticancer activity. COH29 inhibits α and β subunit of RNR with IC50s of 16 μM. price>
R-R-4626 L189 CAS No.64232-83-3 L189/CAS No.64232-83-3 is a DNA ligase inhibitor. L189 has inhibition effect for DNA Ligase I, III and IV with IC50 values of 5 μM, 9 μM and 5 μM, respectively. L189 has no cytotoxicity and individually increase cell death. L189 can be used for the research of cancer. price>
R-C-2958 PLA-PEOz-SH Poly(D,L-lactide)-Poly(2-ethyl-2-oxazoline)is an amphiphilic AB block copolymer,it can be used to prepare PH responsivemicelle for drug delivery,PLA can choose DLLA or LLA.It is a pH responsive amphiphilic copolymer product price>
R-R-4627 APE1-IN-1 CAS No.524708-03-0 APE1-IN-1/CAS No.524708-03-0 is a potent and blood-brain barrier (BBB) penetrant apurinic/apyrimidinic (AP) endonuclease 1 (APE1) inhibitor with an IC50 value of 2 μM. APE1-IN-1 can potentiate the cytotoxicity of the alkylating agents Methylmethane sulfonate and Temozolomide (HY-17364) to cancer cells. price>
R-R-4628 Galidesivir hydrochloride CAS No.222631-44-9 Galidesivir (BCX4430) hydrochloride/CAS No.222631-44-9, an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity. Galidesivir hydrochloride is active in vitro against many RNA viral pathogens, including the filoviruses and emerging infectious agents such as MERS-CoV, SARS-CoV, and SARS-CoV-2. Galidesivir hydrochloride inhibits some negative-sense RNA viruses with EC50s ranging from ~3 to ~68 μM. price>
R-C-2959 PLGA-PEOz-MAL Poly(L-lactide-co-glycolide)-Poly(2-ethyl-2-oxazoline)is an amphiphilic AB block copolymer,it can be used to prepare PH responsivemicelle for drug delivery, LA:GA:75:25/50:50. price>
R-R-4629 Bractoppin CAS No.2290527-07-8 Bractoppin/CAS No.2290527-07-8 is a potent and selective agent-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem(t) BRCT domain (binding IC50: 74 nM). Bractoppin diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51. Bractoppin preferentially inhibits BRCA1 tBRCT-dependent steps in the DNA damage response. price>
R-C-2960 DSPE-TK-PEOz DSPE(1,2-distearyl-sn-glycerin-3-phosphate ethanolamine) is a saturated 18 carbon phospholipid, which is commonly used in the synthesis of liposomes. Polyethylene glycol (PEG)-coupled DSPE is hydrophilic and can be used for drug delivery,gene transfection and biomolecular modification. At present, the mainly include synthetic phospholipids, PEG derivatives, block copolymers, gold nanoparticles, magnetic nanoparticles, mesoporous silica, reactive fluorescent dyes, fluorescent quantum dots, click chemistry and macrocyclic ligands. price>
R-R-4630 Lapachol CAS No.84-79-7 Lapachol/CAS No.84-79-7, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity. price>
R-C-2961 5-(4-hydroxyphenyl)-10,15,20-(4-methylphenyl) porphine Porphyrin is a complex nitrogen-containing compound based on the structure of four pyrrole nuclei closed into ten J six rings. It is changed from animal and plant pigments (chlorophyll or heme). These pigments contain pyrrole nuclei. It mainly exists in the form of metal complexes (vanadium, nickel, iron, copper, cobalt, zinc, etc.) and they are very stable price>