Product apis-angiogenesis

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Catalog	name	Description	price
R-C-1596	Daprodustat(GSK1278863) CAS:960539-70-2	Daprodustat(GSK1278863)is an orally active hypoxia-inducible factor prolyl hydroxylase(HIF-PH)inhibitor being developed for the treatment of anemia associated with chronic kidney disease.	price>
R-C-1597	CH5183284(Debio-1347) CAS:1265229-25-1	CH5183284(Debio-1347,FF284)is a selective and orally available FGFR inhibitor with IC50 of 9.3nM,7.6nM,22 nM,and 290nM for FGFR1,FGFR2,FGFR3,and FGFR4, respectively.	price>
R-C-1619	BFH772 CAS ：890128-81-1	BFH772,a structure analogue of BAW2881,is a potent and selective VEGF inhibitor.BFH772 is highly effective at targeting VEGFR2 kinase with an IC50 value of 3 nM.BFH772 inhibits the ligand induced autophosphorylation of RET, PDGFR,and KIT kinases,with IC50 values ranging between 30 and 160 nM.	price>
R-C-1715	CNX774 CAS:1202759-32-7	CNX-774 is an orally active,irreversible and selective BTK inhibitor,with an IC50 of <1nM.CNX-774 specifically targets Cysteine 481 of Btk for covalent modification.	price>
R-C-1722	PD-166866 CAS:192705-79-6	PD166866 is a FGFR1 inhibitor with IC50 value of 55 nM,and no effect on c-Src, PDGFR-b,EGFR or insulin receptor tyrosine kinases or MEK,PKC,and CDK4.	price>
R-C-1743	AST 487 CAS:630124-46-8	AST-487(NVP-AST487),a N,N-diphenyl urea,is an ATP competitive inhibitor of Flt3 with ki of 0.12 μM.Besides FLT3,AST487 also inhibits RET,KDR,c-KIT,and c-ABL kinase with IC50 values below 1μM.	price>
R-C-1760	TAK-659 CAS：1952251-28-3	TAK-659 is a potent and selective inhibitor of spleen tyrosine kinase(SYK)with an IC50 value of 3.2 nM.It is selective against most other kinases,but potent toward both SYK and FLT3.	price>
R-C-1773	BAY-61-360 CAS:648903-57-5	BAY-61-3606 is a potent and selective inhibitor of Syk kinase(Ki=7.5nM).BAY-61-3606 induces cell cycle arrest and apoptosis.	price>
R-C-1858	Bafetinib (INNO-406) CAS:859212-16-1	Bafetinib(INNO-406,NS-187)is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8nM/19nM in cell-free assays,does not inhibit the phosphorylation of the T315I mutant and is less potent to PDGFR and c-Kit.	price>
R-C-1859	IOX4 CAS:1154097-71-8	IOX4 is a selective HIF prolyl-hydroxylase 2(PHD2)inhibitor with an IC50 value of 1.6nM,induces HIFα in cells and in wildtype mice with marked induction in the brain tissue.IOX4 competes with and displaces 2-oxoglutarate(2OG)at the active site of PHD2.	price>

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