Product apis-apoptosis

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Catalog	name	Description	price
R-R-1907	Bax activator-1 CAS No.1638526-94-9	Bax activator-1 (compound 106)/CAS No.1638526-94-9 is a Bax activator that induces Bax-dependent tumor cell apoptosis.	price>
R-R-1908	Z-Asp-CH2-DCB CAS No.153088-73-4	Z-Asp-CH2-DCB/CAS No.153088-73-4 is an irreversible broad spectrum caspase inhibitor. Z-Asp-CH2-DCB also inhibits proteases with caspase-like activity. Z-D-CH2-DCB blocks the production of IL-1β, TNF-α, IL-6, and IFN-γ in staphylococcal enterotoxin B (SEB)-stimulated peripheral blood mononuclear cells (PBMC), and reduces SEB-1-stimulated T-cell proliferation in a dose-dependent manner. Z-Asp-CH2-DCB prevents SU5416-induced septal cell apoptosis and emphysema development.	price>
R-R-1909	Oligomycin B CAS No.11050-94-5	Oligomycin B/CAS No.11050-94-5 is an antibiotic isolated from marine Streptomyces, used as an eukaryotic ATP synthase inhibitor, induces apoptosis.	price>
R-R-1910	Pimpinellin CAS No.131-12-4	Pimpinellin/CAS No.131-12-4 is a constituent of Cyrtomium fortumei (J.). Pimpinellin inhibits the growth of tumor cells via the induction of tumor cell apoptosis.	price>
R-R-1911	6-Hydroxykaempferol 3-O-β-D-glucoside CAS No.145134-61-8	6-Hydroxykaempferol 3-O-β-D-glucoside/CAS No.145134-61-8 possesses anticancer activity and induces apoptosis.	price>
R-R-1912	(R)-CR8 trihydrochloride CAS No.1786438-30-9	(R)-CR8 (CR8) trihydrochloride/CAS No.1786438-30-9, a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 trihydrochloride inhibits CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)-CR8 trihydrochloride induces apoptosis and has neuroprotective effect. (R)-CR8 trihydrochloride acts as a molecular glue degrader that depletes cyclin K.	price>
R-R-1913	AZD5582 dihydrochloride CAS No.1883545-51-4	AZD5582 dihydrochloride/CAS No.1883545-51-4 is an antagonist of the inhibitor of apoptosis proteins (IAPs), which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. AZD5582 induces apoptosis.	price>
R-R-1914	12-HETE CAS No.71030-37-0	12-HETE/CAS No.71030-37-0, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway.12-HETE has both anti-thrombotic and pro-thrombotic effects. 12-HETE is a neuromodulator.	price>
R-R-1915	Apostatin-1 CAS No.2559703-06-7	Apostatin-1 (Apt-1)/CAS No.2559703-06-7 is a potent TRADD inhibitor. Apostatin-1 can bind with TRADD-N (KD=2.17 μM), disrupting its binding to both TRADD-C and TRAF2. Apostatin-1 modulates the ubiquitination of RIPK1 and beclin 1. Apostatin-1 blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, α-synuclein, or huntingtin.	price>
R-R-1916	Lometrexol disodium CAS No.120408-07-3	Lometrexol (DDATHF) disodium/CAS No.120408-07-3, an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol disodium can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol disodium has anticancer activity. Lometrexol disodium also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor.	price>

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