Product apis-apoptosis

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Catalog	name	Description	price
R-R-1978	Almorexant CAS No.871224-64-5	Almorexant (ACT 078573)/CAS No.871224-64-5 is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant totally blocked the intracellular Ca2+ signal pathway. Almorexant stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis.	price>
R-R-1979	Isatuximab CAS No.1461640-62-9	Isatuximab/CAS No.1461640-62-9 is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma (MM). Isatuximab has antitumor activity via multiple biological mechanisms, including antibody-dependent cellular-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis, and direct induction of apoptosis without crosslinking. Isatuximab also directly inhibits CD38 ectoenzyme activity, which is implicated in many cellular functions.	price>
R-R-1980	MG-101 CAS No.110044-82-1	MG-101 (ALLN)/CAS No.110044-82-1 is an inhibitor of cysteine proteases which inhibits calpain I, calpain II, cathepsin B and cathepsin L with Kis of 190, 220, 150 and 500 pM, respectively. MG-101 induces apoptosis and inhibits tumor growth, it can be used for the research of colon cancer.	price>
R-R-1981	Ceranib-2 CAS No.1402830-75-4	Ceranib-2/CAS No.1402830-75-4 is a potent and nonlipid ceramidase inhibitor that inhibits cellular ceramidase activity with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 induces the accumulation of multiple ceramide species, decreases levels of sphingosine and sphingosine-1-phosphate (S1P), and induces cell apoptosis. Anticancer activity.	price>
R-R-1982	Tricetin CAS No.520-31-0	Tricetin/CAS No.520-31-0 is a potent competitive inhibitor of the Keap1-Nrf2 Protein Protein Interaction (PPI). Tricetin protects against 6-OHDA-induced neurotoxicity in the Parkinsonism model by activating the Nrf2/HO-1 signaling pathway and preventing the mitochondria-dependent apoptosis pathway.	price>
R-R-1983	1G244 CAS No.847928-32-9	1G244/CAS No.847928-32-9 is a potent DPP8/9 inhibitor with IC50s of 12 nM and 84 nM, respectively. 1G244 does not inhibit DPPIV and DPPII. 1G244 induces apoptosis in multiple myeloma cells and has anti-myeloma effects.	price>
R-R-1984	Apoptolidin CAS No.194874-06-1	Apoptolidin/CAS No.194874-06-1 is a polyketide isolated from Nocardiopsis bacteria. Apoptolidin is a selective mitochondrial F1FO ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC50=10-17 ng/ml) but not in normal cells.	price>
R-R-1985	TL4-12 CAS No.1620820-12-3	TL4-12/CAS No.1620820-12-3 is a selective MAP4K2/GCK inhibitor, dose-dependently downregulates IKZF1 and BCL-6 and leads to MM cell proliferation inhibition (IC50=37 nM) accompanied by induction of apoptosis. TL4-12 can be used to overcome immunomodulatory agent resistance in multiple myeloma (MM).	price>
R-R-1986	HLI373 dihydrochloride CAS No.1782531-99-0	HLI373 dihydrochloride/CAS No.1782531-99-0 is an efficacious Hdm2 inhibitor. HLI373 dihydrochloride inhibits the ubiquitin ligase activity of Hdm2. HLI373 dihydrochloride is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents. Antimalarial activity.	price>
R-R-1987	Etoposide phosphate CAS No.117091-64-2	Etoposide phosphate (BMY-40481)/CAS No.117091-64-2 is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate is the phosphate ester proagent of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate induces cell cycle arrest, apoptosis, and autophagy.	price>

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