Product apis-protein-tyrosine-kinase

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Catalog	name	Description	price
R-C-1369	AZ5104 CAS：1421373-98-9 CAS：1421373-98-9	AZ 5104 is an active,demethylated metabolite of AZD 9291,an irreversible inhibitor of EGFR-sensitizing and T790M resistance mutations(IC50s=15-17nM) that spares the wild-type form of the receptor(IC50=480 nM).1,2,3 AZ 5104 displays a similar overall activity profile as the parent compound.	price>
R-C-1374	E7050 CAS：928037-13-2	Golvatinib,also known as E7050,is an orally bioavailable dual kinase inhibitor of c-Me,(hepatocyte growth factor receptor)and VEGFR-2(vascular endothelial growth factor receptor-2)tyrosine kinases with potential antineoplastic activity.c-Met/VEGFR kinase inhibitor E7050 binds to and inhibits the activities of both c-Met and VEGFR-2,which may inhibit tumor cell growth and survival of tumor cells that overexpress these receptor tyrosine kinases.c-Met and VEGFR-2 are upregulated in a variety of various tumor cell types and play important roles in tumor cell growth,migration and angiogenesis.	price>
R-C-1382	Volitinib CAS:1313725-88-0	Savolitinib,also known as Volitinib,AZD6094 or HMPL-504,is an orally bioavailable inhibitor of the c-Met receptor tyrosine kinase with potential antineoplastic activity.Volitinib selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner,and disrupts c-Met signal transduction pathways.This may result in cell growth inhibition in tumors that overexpress the c-Met protein.	price>
R-C-1407	1-NA-PP1 CAS:221243-82-9	1-NA-PP1 is a selective inhibitor of v-Src and c-Fyn as well as c-Abl.	price>
R-C-1408	1-NM-PP1 CAS:221244-14-0	1-NM-PP1,a cell-permeable PP1 analog,is a potent Src family kinases inhibitor with IC50s of 4.3nM and 3.2nM for v-Src-as1 and c-Fyn-as1,respectively.	price>
R-C-1413	G-749 CAS:1457983-28-6	G-749 is a novel FLT3 inhibitor that showed potent and sustained inhibition of the FLT3 wild type and mutants including FLT3-ITD,FLT3-D835Y,FLT3-ITD/N676D,and FLT3-ITD/F691L in cellular assays.G-749 retained its inhibitory potency in various drug-resistance milieus such as patient plasma,FLT3 ligand surge,and stromal protection.	price>
R-C-1437	AG18 CAS：118409-57-7	AG-18（RG-50810;RG-50858;TX 825;Tyrphostin A23;Tyrphostin AG-18）AG-18 is an inhibitor of epidermal growth factor(EGF)receptor kinase with an IC50 value of 35 µM in the human epidermoid carcinoma cell line A431.AG-18 inhibits internalization of the transferrin receptor by perturbing the interaction between tyrosine motifs and the medium chain subunit of the AP-2 adaptor complex.	price>
R-C-1482	CNX-2006 CAS：1375465-09-0	CNX-2006 is a potent,mutant-selective EGFR inhibitor with excellent in vitro activity in cells with activating EGFR mutations,as well as in cells harbouring the T790M mutation.CNX-2006 is the prototype for CO-1686,which is currently in a Phase I clinical trial for the treatment of EGFR-mutant lung cancer.	price>
R-C-1487	Pazopanib (GW786034) CAS：444731-52-6	Pazopanib(GW786034)is a novel multi-target inhibitor of VEGFR1,VEGFR2,VEGFR3,PDGFRβ,c-Kit,FGFR1,and c-Fms with IC50s of 10,30,47, 84,74,140 and 146 nM,respectively.	price>
R-C-1504	azd2932 CAS:883986-34-3	AZD-2932 is a high affinity inhibitor of VEFGR-2 and PDGFR.AZD-2932 has a balanced ~1:1 ratio of activity vs both VEGFR-2 and PDGFRβ and shows IC50 values of 8 and 4 nM against the two enzymes,respectively.It is also active on c-Kit and FLT3 with good selectivity on a panel of kinases.	price>

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