Product apis-transmembrane-transporters

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Catalog	name	Description	price
R-C-2330	Bay K 8644 CAS:71145-03-4	Bay K 8644,a dihydropyridine compound,is a specific L-type Ca2+channel agonist.Bay K 8644 increases Ca2+ influx through sarcolemmal Ca2+channels by increasing the open time of the channel.	price>
R-C-2392	Dronedarone CAS:141626-36-0	Dronedarone(SR33589)is a derivative of amiodarone which is classified as a Class III antiarrhythmic agent.It shows rate-dependent inhibition of the rapid Na+ current,inhibits α and β-adrenergic receptors like Class II agents,exhibits blockade of K+ outward currents as the main mechanism of action of Class III, and effectively block slow Ca2+ inward currents(Class IV).	price>
R-C-2451	Ivermectin (MK-933) CAS： 70288-86-7	Ivermectin(MK-933)is a broad-spectrum anti-parasite agent.Ivermectin(MK-933)is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus.It is a positive allosteric effector of P2X4 and the α7 neuronal nicotinic acetylcholine receptor(nAChRs).Ivermectin also inhibits bovine herpesvirus1(BoHV-1)replication and inhibits BoHV-1 DNA polymerase nuclear import.Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19.	price>
R-C-2523	Tezacaftor (VX-661) CAS:1152311-62-0	Tezacaftor（VX-661）is CFTR modulator.VX-661 is potentially useful for treatment of cystic fibrosis disease.Cystic fibrosis(CF)is a genetic disease caused by defects in the CF transmembrane regulator(CFTR)gene,which encodes an epithelial chloride channel.	price>
R-C-2524	SB705498 CAS：501951-42-4	SB-705498 is a potent,selective and orally bioavailable transient receptor potential vanilloid 1(TRPV1)receptor antagonist with a pIC50 of 7.1.	price>
R-C-2525	GlyH101 CAS：328541-79-3	GlyH-101 is a CFTR inhibitor(cystic fibrosis transmembrane conductance regulator).GlyH-101 is a glycine hydrazide that has been shown to block CFTR channels.GlyH-101 blocks the open pore of cardiac CFTR channels at an electrical distance of 0.15 Â±0.03 from the external membrane surface.	price>
R-C-2526	Ataluren (PTC124) CAS：775304-57-9	Ataluren(PTC124)selectively induces ribosomal read-through of premature but not normal termination codons,with EC50 of 0.1μM in HEK293 cells,may provide treatment for genetic disorders caused by nonsense mutations.	price>
R-C-2527	Vinpocetine CAS：42971-09-5	Vinpocetine(Ethyl apovincaminate)is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels.The IC50 value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17μM.Vinpocetine is a phosphodiesterase(PDE)inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex(IKK).	price>
R-C-2534	AMG073 CAS：226256-56-0	Cinacalcet(AMG073,Sensipar,Cin)is an orally active,allosteric agonist of receptors for calcium(CaR)that increases the sensitivity of the CaR to Ca.	price>
R-C-2773	A-867744 CAS:1000279-69-5	A-867744 is a highly potent and selective type II positive allosteric modulator(PAM)of the alpha7 nicotinic acetylcholine receptors(nAChR)with an EC50 of 1.0μM.	price>

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