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Catalog	name	Description	price
R-R-2331	Tofacitinib-d3 citrate CAS No.2701680-77-3	Tofacitinib-d3 (citrate)/CAS No.2701680-77-3 is deuterium labeled Tofacitinib (citrate). Tofacitinib citrate is an orally available JAK1/2/3 inhibitor with IC50s of 1, 20, and 112 nM, respectively. Tofacitinib citrate has antibacterial, antifungal and antiviral activities.	price>
R-C-632	Aprepitant (MK-0869) cas:170729-80-3	Aprepitant is classified as an NK1 antagonist.Aprepitant has been shown to inhibit both the acute and delayed emesis induced by cytotoxic chemotherapeutic drugs by blocking substance P landing on receptors in the brains neurons.It has also been shown to increase the activity of the 5-HT3 receptor antagonists ondansetron and the corticosteroid dexamethasone,which are also used to prevent nausea and vomiting caused by chemotherapy.	price>
R-R-2332	Ilginatinib maleate CAS No.1354799-87-3	Ilginatinib maleate (NS-018 maleate)/CAS No.1354799-87-3 is a highly active and orally bioavailable JAK2 inhibitor, with an IC50 of 0.72 nM, 46-, 54-, and 31-fold selectivity for JAK2 over JAK1 (IC50, 33 nM), JAK3 (IC50, 39 nM), and Tyk2 (IC50, 22 nM).	price>
R-C-633	sp-420 cas:1221411-72-8	SP-420 is an orally active small molecule that selectively binds iron and removes it from the body.In animal studies,SP-420 has shown excellent tissue penetration, highly efficient iron binding and a promising safety profile.	price>
R-R-2333	Oclacitinib CAS No.1208319-26-9	Oclacitinib/CAS No.1208319-26-9 is a novel JAK inhibitor. Oclacitinib is most potent at inhibiting JAK1 (IC50=10 nM).	price>
R-C-634	CP868596 cas:670220-88-9	Crenolanib(CP-868596,ARO 002)is a potent and selective inhibitor of PDGFRα/βwith Kd of 2.1 nM/3.2 nM in CHO cells,also potently inhibits FLT3,sensitive to D842V mutation not V561D mutation,>100-fold more selective for PDGFR than c-Kit,VEGFR-2,TIE-2,FGFR-2,EGFR,erbB2,and Src.Crenolanib helps to induce mitophagy.	price>
R-R-2334	Pumecitinib CAS No.2401057-12-1	Pumecitinib/CAS No.2401057-12-1 is a Janus kinase (JAK) inhibitor with anti-inflammatory activity.	price>
R-C-635	ZCL278 cas:587841-73-4	ZCL-278 is a selective inhibitor of Cdc42.Targets the binding site of the Cdc42 guanine nucleotide exchange factor,intersectin(ITSN).Inhibits Cdc42-mediated cellular effects,including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons.Also suppresses cell motility and migration in PC3 cells,without cytotoxic effects.	price>
R-R-2335	Povorcitinib phosphate CAS No.1637677-33-8	Povorcitinib (INCB54707) phosphate/CAS No.1637677-33-8 is a potent and selective JAK1 inhibitor that effectively reduces abscesses and inflammatory nodules. Povorcitinib phosphate can be used to study cutaneous lupus erythematosus (CLE) and lichen planus (LP) (information extracted from patent WO2021076124A1).	price>
R-C-636	NSC 405020 cas:7497-07-6	NSC 405020 is a novel small molecule inhibitor of MT1-MMP that specifically targets PEX domain rather than the catalytic domain of MT1-MMP with IC50 >100 μM and does not inhibit the catalytic activity of MT1-MMP or MMP-2.	price>
R-R-2336	JAK-IN-3 CAS No.1400876-94-9	JAK-IN-3 (compound 22)/CAS No.1400876-94-9 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively.	price>
R-C-637	PENTOSTATIN cas:53910-25-1	Pentostatin is a potent inhibitor of adenosine deaminase.The drug is effective in the treatment of many lymphoproliferative malignancies,particularly hairy-cell leukemia.It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.	price>
R-R-2337	JAK-IN-1 CAS No.1334673-53-8	JAK-IN-1/CAS No.1334673-53-8 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively. JAK-IN-1 shows improved selectivity for JAK3 over JAK1.	price>
R-R-2338	JAK-IN-26 CAS No.2417134-93-9	JAK-IN-26 (compound 2)/CAS No.2417134-93-9 is an orally active JAK inhibitor with good pharmacokinetic characteristics. JAK-IN-26 inhibits IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells (IC50=17.2 nM).	price>
R-C-639	SB505124 cas:694433-59-5	SB-505124 is a selective inhibitor of transforming growth factor-β type I receptor (ALK5),ALK4 and ALK7(IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively).	price>
R-R-2339	GS-829845 CAS No.1257705-09-1	GS-829845/CAS No.1257705-09-1 is a major, active metabolite of Filgotinib (HY-18300). GS-829845 is a JAK1 preferential inhibitor but is approximately 10-fold less potent than the parent and with a longer half-life.	price>
R-C-640	Pirodavir cas:124436-59-5	Pirodavir is a potent,broad-spectrum picornavirus inhibitor,and is highly active against both group A and group B rhinovirus serotypes.Pirodavir is very potent in a virus yield reduction assay(IC90=2.3 nM).	price>
R-R-2340	SJ1008030 formic	SJ1008030 (compound 8) formic is a JAK2 PROTAC which selectively degrades JAK2. SJ1008030 formic inhibits MHH–CALL-4 cell growth with an IC50 of 5.4 nM. SJ1008030 formic can be used for the research of leukemia.	price>
R-C-641	PD169316 cas:152121-53-4	PD 169316 is a potent,cell-permeable and selective p38 MAP kinase inhibitor, with IC50 of 89 nM.PD169316 selectively inhibits the kinase activity of the phosphorylated p38 without hindering upstream kinases to phosphorylate p38. PD169316 shows antiviral activity against Enterovirus71.PD169316 shows antiviral activity against Enterovirus71.	price>
R-R-2341	Itacnosertib (hydrocholide) CAS No.2409543-84-4	Itacnosertib hydrocholide/CAS No.2409543-84-4 is an inhibitor of JAK2, ACVR1 (ALK2) and ALK5.	price>

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