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Catalog	name	Description	price
R-R-2721	(R)-ADX-47273 CAS No.851881-59-9	(R)-ADX-47273/CAS No.851881-59-9 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation .	price>
R-C-1022	PD0332991（Palbociclib） CAS No. 571190-30-2	Palbociclib(PD 0332991)is a selective CDK4 and CDK6 inhibitor with IC50s of 11 and 16 nM,respectively.Palbociclib has the potential for ER-positive and HER2-negative breast cancer research.	price>
R-R-2722	VU0155041 CAS No.1093757-42-6	VU0155041/CAS No.1093757-42-6 is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively.	price>
R-C-1023	CW069 CAS No. 1594094-64-0	CW069 is a novel allosteric inhibitor of microtubule kinesin hset.Its IC50 value is 75±20μm,which is significantly selective compared with KSP.IC50 value:75 ± 20μm[1]target:hset-cw069 has obvious selectivity for hset in vitro.The IC50 value of cw069 for hset was 75±20μm,and the selectivity of cw069 for KSP reached the experimental limit.CW069 induced a small but significant increase in the multipolar spindle of MDA-MB-231,which was consistent with the intermediate level of centrosome in untreated cells.After cw069 treatment,the number of multipolar spindles increased in bt549 cells.	price>
R-R-2723	VU0483605 CAS No.1623101-11-0	VU0483605/CAS No.1623101-11-0 is a potent and brain-penetrated mGlu1 receptor positive allosteric modulator (PAM). VU0483605 shows excellent mGlu1 PAM activity at both human and rat, with EC50 values of 390 and 356 nM, respectively.	price>
R-C-1024	TMP269 CAS No. 1314890-29-3	TMP269 is a novel and selective class IIa histone deacetylase(HDAC)inhibitor with IC50s of 157 nM,97nM,43 nM and 23 nM for HDAC4,HDAC5,HDAC7 and HDAC9, respectively.	price>
R-R-2724	AZ 12216052 CAS No.1290628-31-7	AZ 12216052/CAS No.1290628-31-7 is a mGluR8 positive allosteric modulator, and helps mGluR8 modulate signaling inputing to retinal ganglion cells. AZ 12216052 exhibits antianxiety effect.	price>
R-C-1025	Nexturastat A CAS No. 1403783-31-2	Nexturastat A is a selective inhibitor of histone deacetylase 6(HDAC6)with IC50 value of 5.2 nM.Nexturastat A is a HDAC inhibitor.It was developed by structural modification of aryl urea HDACIs.The inhibitory activity of Nexturastat A is most potent against HDAC6 with IC50 value of 5.2 nM. Besides that,Nexturastat A also shows inhibition of other HDACs with IC50 values of 3.02,6.92,6.68,9.39, 11.7,4.46,0.954,6.72,7.57and5.14μM for HDAC1,2,3,4,5,7,8,9,10 and 11,respectively.Nexturastat A has been shown to suppress cell proliferation and promote apoptosis in B16 murine melanoma cells.	price>
R-R-2725	LSN2463359 CAS No.1401031-52-4	LSN2463359/CAS No.1401031-52-4 is positive allosteric modulator of metabotropic glutamate 5 (mGlu5). LSN2463359 attenuates aspects of the behavioral response to administration of the competitive NMDA receptor antagonist. LSN2463359 selectively attenuates reversal learning deficits observed in the neurodevelopmental MAM E17 model. LSN2463359 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-1026	kartogenin CAS No. 4727-31-5	Kartogenin(KGN)is an inducer of differentiation of human mesenchymal stem cells into chondrocytes,with an EC50 of 100 nM. Kartogenin binds filamin A,disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ),and induces chondrogenesis by regulating the CBFβ-RUNX1 transcriptional program.Kartogenin can be used for the research of osteoarthritis(OA).	price>
R-R-2726	LY2812223 CAS No.1311385-20-2	LY2812223/CAS No.1311385-20-2 is a highly potent, functionally selective mGlu2 receptor agonist with mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively).	price>
R-C-1027	Deferitrin C AS NO. 239101-33-8	Deferitrin is a novel, orally available iron chelator.Deferitrin may be useful as chelation monotherapy or as part of combination or doublet chelation therapy for the treatment of severe iron overload in patients with beta-thalassemia major if its favorable pharmacokinetic profile,efficacy,safety and tolerability are confirmed in more extensive clinical trials.A phase I/II clinical trial that began in September 2003 has reportedly completed recruitment.Deferitrin was safe,well-tolerated,and well-absorbed either with food and fasting in beta-thalassemia patients.Renal excretion of deferitrin uncomplexed with iron was similar to that seen in preclinical studies,which predict iron excretion to be via the fecal route.Further studies are ongoing to define the effect of deferitrin on iron balance.	price>
R-R-2727	LY487379 CAS No.353231-17-1	LY487379/CAS No.353231-17-1 is a selective human mGluR2 positive allosteric modulator (PAM). LY487379 potentiates glutamate-stimulated [35S]GTPγS binding with EC50 values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 can be used for schizophrenia research.	price>
R-C-1028	SVT-40776 CAS NO. 385367-47-5	SVT-40776 is a potent inhibitor of M(3)receptor-related detrusor contractile activity.SVT-40776 is highly selective for M(3) over M(2)receptors(Ki=0.19 nmol.L(-1)for M(3)receptor affinity).SVT-40776 was the most potent in inhibiting carbachol-induced bladder contractions of the anti-cholinergic agents tested, without affecting atrial contractions over the same range of concentrations. SVT-40776 exhibited the highest urinary versus cardiac selectivity(199-fold).	price>
R-R-2728	E4CPG CAS No.170846-89-6	E4CPG ((RS)-ECPG)/CAS No.170846-89-6 is a Group I/Group II metabotropic glutamate receptor (mGluR) antagonist. E4CPG can inhibit the paired-pulse ratio of monosynaptic inhibitory postsynaptic currents (IPSC) potentiation.	price>
R-C-1029	Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222) CAS No. 66584-72-3	Ansamitocin P-3 is a microtubule inhibitor,it is also a macrocyclic antitumor antibiotic.Ansamitocin P3 inhibits the proliferation of MCF-7,HeLa,EMT-6/AR1 and MDA-MB-231 cells in culture.Further,Ansamitocin P3 binds to purified tubulin in vitro with a dissociation constant Kd value of 1.3±0.7 µM.	price>
R-R-2729	YM-298198 hydrochloride CAS No.1216398-09-2	YM-298198 hydrochloride/CAS No.1216398-09-2 is a high-affinity, selective, orally active, and non-competitive antagonist of metabotropic glutamate receptor type 1 (mGluR1). YM-298198 hydrochloride can be used for the research of neurological disorders.	price>
R-C-1030	Valrubicin CAS No. 56124-62-0	Valrubicin is a chemotherapy drug used to treat bladder cancer.Valrubicin is a chemotherapy agent,inhibits TPA-and PDBu-induced PKC activation with IC50s of 0.85 and 1.25μM,respectively.	price>
R-R-2730	FTIDC CAS No.873551-53-2	FTIDC/CAS No.873551-53-2 is an orally active, noncompetitive, selective allosteric metabotropic glutamate receptor (mGluR) 1 antagonist with an IC50 of 5.8 nM for human mGluR1a. FTIDC has no species differences in its antagonistic activity on recombinant human, mouse, and rat mGluR1.	price>
R-C-1031	Pirarubicin CAS No. 72496-41-4	Pirarubicin is an analogue of the anthracycline anti-neoplastic doxorubicin. Intercalates into DNA and interacts with Topo II(topoisomerase II)and supressing DNA replication.	price>

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