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Catalog	name	Description	price
R-C-1052	AMG-47a CAS No. 882663-88-9	AMG-47a is a potent,nonselective inhibitor of Lck kinase with IC50 of 3.4 uM and it also inhibits T cell proliferation.AMG-47a exhibit anti-inflammatory activity(ED50)of 11 mg/kg in the anti-CD3-induced production of interleukin-2 (IL-2)in mice.	price>
R-R-2752	DFMTI CAS No.864864-86-8	DFMTI/CAS No.864864-86-8 can completely block the rmGlu1 L757V glutamate response.	price>
R-C-1053	Tazemetostat (EPZ-6438) CAS No. 1403254-99-8	Tazemetostat(EPZ-6438,E7438)is a potent,and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays,exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs.	price>
R-R-2753	Mavoglurant racemate CAS No.1636881-61-2	Mavoglurant racemate (AFQ-056 racemate)/CAS No.1636881-61-2 is the racemate of Mavoglurant. Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist. Mavoglurant (racemate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-1054	EPz005687 CAS:1396772-26-1	EPZ005687 is a potent and selective inhibitor of EZH2 with Ki of 24 nM,and has 50-fold selectivity against EZH1 and 500-fold selectivity against 15 other protein methyltransferases.	price>
R-R-2754	VU6010572 CAS No.2126784-39-0	VU6010572/CAS No.2126784-39-0 is a potent and selective mGlu3 negative allosteric modulator with IC50 of 245 nM. VU6010572 is highly CNS penetrant.	price>
R-C-1055	4EGI-1 CAS:315706-13-9	4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 μM.4EGI-1 specifically inhibits the function of mTOR by blocking the activation of 4E-BP1.4EGI-1 induces apoptosis.	price>
R-R-2755	VU0155094 CAS No.731006-86-3	VU0155094/CAS No.731006-86-3 is a positive allosteric modulator with differential activity at the various group III mGluRs.	price>
R-R-2756	(rel)-Eglumegad CAS No.176027-90-0	(rel)-Eglumegad ((rel)-LY354740)/CAS No.176027-90-0 is a relative configuration of Eglumegad (HY-18941). Eglumegad is a highly potent and selective group II (mGlu2/3) receptor agonist with EC50s of 5 and 24 nM for transfected human mGlu2 and mGlu3 receptors, respectively.	price>
R-C-1057	EHT 1864 2HCl CAS: 754240-09-0	EHT 1864 is an inhibitor of Rac family small GTPases.EHT 1864 directly binds and impairs the ability of this small GTPase to engage critical downstream effectors required for growth transformation.The Kd values are 40,50,60,and 230 nM for Rac1,Rac1b,Rac2 and Rac3,respectively.EHT 1864 also potently inhibits other Rac-dependent transformation processes,Tiam1- and Ras-mediated growth transformation.EHT 1864 prevents Aβ 40 and Aβ 42 production in vivo.	price>
R-R-2757	rel-ACPT-I CAS No.194918-76-8	rel-ACPT-I/CAS No.194918-76-8 is an agonist of group III mGluRs with diverse biological activities including neuroprotective, anticonvulsant, and anxiolytic-like effects.	price>
R-C-1058	INH1 CAS:313553-47-8	INH1 specifically disrupts the Hec1/Nek2 interaction via direct Hec1 binding. INH1 shows promising cancer inhibition activity both in vitro and in vivo.	price>
R-R-2758	A-841720 CAS No.869802-58-4	A-841720/CAS No.869802-58-4 is a potent, non-competitive and selective mGlu1 receptor antagonist with an IC50 of 10 nM for human mGlu1 receptor. A-841720 displays 34-fold selectivity over mGlu5 (IC50 of 342 nM), and no significant activity at a range of other neurotransmitter receptors, ion channels, and transporters. A-841720 has the potential for chronic pain research.	price>
R-C-1059	INH6 CAS：1001753-24-7	INH6 is a potent Hec1 inhibitor,which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment.	price>
R-R-2759	XAP044 CAS No.196928-50-4	XAP044/CAS No.196928-50-4 is a potent and selective antagonist of mGlu7. The metabotropic glutamate receptor subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral paradigms.	price>
R-C-1060	E7010(ABT-751) CAS：141430-65-1	ABT-751(E7010)binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules,not a substrate for the MDR transporter and is active against cell lines resistant to vincristine,doxorubicin,and cisplatin.	price>
R-R-2760	(±)-LY367385 CAS No.198419-90-8	(±)-LY367385/CAS No.198419-90-8 is the racemate of LY367385. LY367385 is a highly potent and selective mGluR1a antagonist. LY367385 has an IC50 of 8.8 μM for inhibits of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with > 100 μM for mGlu5a.	price>
R-C-1061	AC55541 CAS：916170-19-9	AC-55541 is a highly selective protease-activated receptor 2(PAR2)agonist (pEC50=6.7),displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation.	price>
R-R-2761	Ro 67-4853 CAS No.302841-89-0	Ro 67-4853/CAS No.302841-89-0 is a positive allosteric modulator (PAM) of mGluR1 (pEC50=7.16 for rmGlu1a receptor). Ro67-4853 exhibits activity at all group I mGlu receptors including hmGlu1, rmGlu1, and rmGlu5. Ro 67-4853 enhances the potency of L-Glu by interacting with the transmembrane domain (TMD) of the receptor. Ro 67-4853 potentiates sensory synaptic responses to repetitive vibrissa stimulation.	price>
R-C-1062	ZK-811752(BX-471) CAS:217645-70-0	BX471(ZK-811752)is an orally active, potent and selective non-peptide CCR1 antagonist with a Ki of 1 nM,and exhibits 250-fold selectivity for CCR1 over CCR2,CCR5 and CXCR4.	price>

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