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Catalog	name	Description	price
R-C-1079	Berzosertib (VE-822) CAS:1232416-25-9	VE-822 is an inhibitor of ataxia-telangiectasia mutated(ATM)Rad3-related protein kinase(ATR),a regulator of DNA damage repair, with Ki and IC50 values of <0.2 and 19 nM,respectively,in pancreatic cancer cells in vitro.1 It is selective for ATR over ATM (Ki=34 nM;IC50=2,600 nM) as well as DNA-PK,mTOR,and PI3Kγ(Kis= >4,000,>1,000,and 220 nM,respectively).In cultured COLO 205 colorectal cancer cells,VE-822(80 nM)reduces the IC50 of the topoisomerase 1 inhibitor SN-38 by at least 8-fold.2 In a mouse xenograft model,it delays the growth of radiation-treated PSN-1 pancreatic cancer xenografts by 2-3-fold relative to radiation alone when administered at a dose of 60 mg/kg.VE-822 also enhances the tumoricidal effects of cisplatin against primary human lung cancer xenografts and the effects of the topoisomerase inhibitor irinotecan against COLO 205 colorectal tumors in mice.	price>
R-R-2779	Telcagepant CAS No.781649-09-0	Telcagepant (MK-0974)/CAS No.781649-09-0 is an orally active calcitonin gene-related peptide (CGRP) receptor antagonist with Kis of 0.77 nM and 1.2 nM for human and rhesus CGRP receptors, respectively.	price>
R-C-1080	VE821 CAS:1232410-49-9	VE-821 is a potent ATP-competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM.	price>
R-R-2780	BCTC CAS No.393514-24-4	BCTC/CAS No.393514-24-4 is an orally active current inhibitor of vanilloid receptor type 1 (VR1). BCTC is a transient receptor potential cation channel subfamily M member 8 (TRPM8) and transient receptor potential vanilloid 1 (TRPV1) antagonist. BCTC is an insulin sensitizer and secretor. BCTC has anticancer and analgesic effects.	price>
R-C-1081	PI3065 CAS:955977-50-1	PI 3065 is a p110δ-selective PI3K inhibitor with Ki and IC50 values of 1.5 nM and 5 nM,respectively.Administration of PI 3065 suppressed 4T1 tumour growth and metastasis,to a similar extent as genetic inactivation of p110δ,marked by initial tumour progression,followed by tumour regression.	price>
R-R-2781	MK-3207 CAS No.957118-49-9	MK-3207/CAS No.957118-49-9 is an orally active, highly selective and species-specific CGRP receptor antagonist (for human CGRP receptor: IC50=0.12 nM; Ki=0.024 nM). MK-3207 can be used for migraine studies.	price>
R-C-1082	Ro 48-8071 fumarate CAS:89197-69-1	Ro 48-8071 blocked human liver OSC and cholesterol synthesis in HepG2 cells in the nanomolar range;in cells it triggered the production of monooxidosqualene, dioxidosqualene,and epoxycholesterol.Administration of Ro 48-8071 to mice with BT-474 tumor xenografts prevented tumor growth,with no apparent toxicity.Ro 48-8071 degraded ERα while concomitantly inducing the anti-proliferative protein ERβ.	price>
R-R-2782	MK-3207 Hydrochloride CAS No.957116-20-0	MK-3207 (Hydrochloride)/CAS No.957116-20-0 is a potent and orally bioavailable CGRP receptor antagonist with IC50 of 0.12 nM and Ki of 0.024 nM, and is highly selective versus human AM1, AM2, CTR, and AMY3.	price>
R-C-1083	TORIN1 CAS：1222998-36-8	Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM.Torin 1 shows over 100-fold selectivity for mTOR over PI3Kα and other PI3K-like kinases, including ATM,DNA-PK,and hVps34,as well as 450 other protein kinases.Torin 1 induces autophagy in HeLa cells.Torin 1 is efficacious at a dose of 20 mg/kg in inhibiting downstream effectors of mTOR in mice.In a recent study,it is reported Torin 1 increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON.	price>
R-R-2783	Atogepant CAS No.1374248-81-3	Atogepant (MK-8031)/CAS No.1374248-81-3 is an orally active and selective calcitonin gene–related peptide receptor (CGRP) antagonist. Atogepant can be used for researching migraine.	price>
R-C-1084	LCL161 CAS:1005342-46-0	LCL161 enhanced the pro apoptotic effect of nilotinib and PKC412 on leukemia in vitro,and enhanced the activity of two kinase inhibitors on leukemia in vivo.In addition,LCL161 synergized with nilotinib in vivo and significantly reduced the burden of leukemia to below the baseline level of inhibition of medium and high dose nilotinib.Finally,LCL161 showed antiproliferative effect on the cells with inherent resistance to tyrosine kinase inhibitors,which was the result of the mutant expression of the compound inhibitory protein target.LCL161 is a small molecule antagonist of apoptosis inhibitor(IAP),with IC50 value of 10.23 μM.lcl161 in Hep3B cells could inhibit the proliferation and activity of Hep3B and PLC5 cells.Lcl161 also had effect on ALCL cell line karpas-299 with IC50 value of 1.6μM.	price>
R-R-2784	Adrenomedullin (1-50), rat	Adrenomedullin (1-50), rat is a 50 amino acid peptide, which induces a selective arterial vasodilation via activation of CGRP1 receptor.	price>
R-C-1085	LY2584702 CAS：1082949-67-4	LY2584702 inhibits ribosomal protein S6 Kinase(p70S6K),and prevents phosphorylation of the S6 subunit of ribosomes,thereby inhibiting normal ribosomal function within tumor cells leading to a decrease in protein synthesis and in cellular proliferation.LY2584702 exhibited anti-tumour activity in preclinical analysis.	price>
R-R-2785	Calcitonin Gene Related Peptide (CGRP) II, rat TFA	Calcitonin Gene Related Peptide (CGRP) II, rat TFA, a CGRP receptor activator, is a potent and long-lasting vasodilator. Calcitonin Gene Related Peptide (CGRP) II TFA can be used in the research of cardiovascular diseases.	price>
R-C-1086	CHIR99021 CAS:252917-06-9	CHIR-99021(CT99021)is a potent and selective GSK-3α/βinhibitor with IC50s of 10 nM and 6.7 nM.CHIR-99021 shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases.CHIR-99021 is also a potent Wnt/β-catenin signaling pathway activator.CHIR-99021 enhances mouse and human embryonic stem cells self-renewal.CHIR-99021 induces autophagy.	price>
R-R-2786	SUN B8155 CAS No.345893-91-6	SUN B8155/CAS No.345893-91-6, a non-peptide agonist of calcitonin (CT) receptor, selectively mimics the biological actions of calcitonin. Calcitonin, a 32-amino acid peptide hormone secreted mainly from the thyroid gland, plays an important role in maintaining bone homeostasis.	price>
R-C-1087	ACTB-1003 CAS：939805-30-8	ACTB-1003 is an oral kinase inhibitor targeting cancer mutations(FGFR inhibition),angiogenesis (inhibition of VEGFR2 and Tie-2)and induces apoptosis (targeting RSK and p70S6K,downstream of PI3 kinase).	price>
R-R-2787	Adrenomedullin (16-31), human CAS No.318480-38-5	Adrenomedullin (16-31), human/CAS No.318480-38-5 is amino acid residues 16-31 fragment of human adrenomedullin (hADM). Adrenomedullin has appreciable affinity for the CGRP1 receptor. Adrenomedullin (16-31), human possesses pressor activity in the systemic vascular bed of the rat, but not the cat.	price>
R-C-1088	RN486 CAS：1242156-23-5	RN486 is a potently and selectively inhibitor.RN486 inhibited the Btk enzyme and displayed functional activities in human cell-based assays in multiple cell types.RN486 blocks Fcε receptor cross-linking-induced degranulation in mast cells (IC(50)=2.9 nM),Fcγ receptor engagement-mediated tumor necrosis factor α production in monocytes(IC(50)=7.0 nM),and B cell antigen receptor-induced expression of an activation marker,CD69,in B cells in whole blood(IC(50)=21.0 nM).RN486 produced robust anti-inflammatory and bone-protective effects in mouse CIA and rat adjuvant-induced arthritis(AIA) models.In the AIA model,RN486 inhibited both joint and systemic inflammation either alone or in combination with methotrexate,reducing both paw swelling and inflammatory markers in the blood.	price>
R-R-2788	Chrysin 6-C-glucoside 8-C-arabinoside CAS No.185145-34-0	Chrysin 6-C-glucoside 8-C-arabinoside/CAS No.185145-34-0 can inhibit the CGRP releasing and the activation of TRPV1 channel. Chrysin 6-C-glucoside 8-C-arabinoside can be used for anti-migraine research.	price>

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