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Catalog	name	Description	price
R-C-1237	Spautin-1 CAS:1262888-28-7	Spautin-1 is a novel autophagy inhibitor,IM inhibited the growth of K562 cells with IC50 of 1.03μM.In contrast,co-treatment with Spautin-1 increased IM-induced inhibition of cell viability with IC50 of 0.45 μM.	price>
R-R-2937	NS-2028 CAS No.204326-43-2	NS-2028/CAS No.204326-43-2 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor with IC50 values of 30 nM and 200 nM for basal and NO-stimulated enzyme activity. NS-2028 inhibits soluble Guanylyl Cyclase activity in homogenates of mouse cerebellum and neuronal NO synthase with IC50 values of 17 nM and 20 nM. NS-2028 inhibits 3-morpholino-sydnonimine (SIN-1)-elicited formation of cyclic GMP in human cultured umbilical vein endothelial cells with an IC50 of 30 nM. NS-2028 is commonly used in the research of nitric oxide signaling pathways, it inhibits NO-dependent relaxant responses in non-vascular smooth muscle completely (1 μM). NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability.	price>
R-C-1238	ONC201(TIC10) CAS:1616632-77-9	TIC10 is a potent,orally active,and stable tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)inducer which acts by inhibiting Akt and ERK, consequently activating Foxo3a and significantly inducing cell surface TRAIL. TIC10 can cross the blood-brain barrier.	price>
R-R-2938	Ataciguat CAS No.254877-67-3	Ataciguat (HMR-1766)/CAS No.254877-67-3 is a nitric oxide-independent soluble guanylate cyclase (sGC) activator. Ataciguat is able to activate the ferric heme-iron redox form of sGC that stimulate the production of cyclic GMP (cGMP). Ataciguat exhibits vasodilator effects.	price>
R-C-1239	R1487 Hydrochloride CAS:449808-64-4	R1487 Hydrochloride is a highly potent and selective p38αinhibitor, with Kd values of 0.2 nM and 29 nM for p38α and p38β,respectively.	price>
R-C-2239	Oroxin B CAS：114482-86-9	Oroxin B(OB)is a flavonoid isolated from traditional Chinese herbal medicine Oroxylum indicum (L.)Vent.Oroxin B(OB)possesses obvious inhibitory effect and induces early apoptosis rather than late apoptosis on liver cancer cells through upregulation of PTEN,down regulation of COX-2,VEGF,PI3K,and p-AKT.	price>
R-R-2939	Cinaciguat hydrochloride CAS No.646995-35-9	Cinaciguat hydrochloride/CAS No.646995-35-9 is a potent soluble guanylate cyclase (GC) activator with EC50 of 15 nM in platelets.	price>
R-C-1240	GSK2256098 CAS:1224887-10-8	GSK2256098,also known as GTPL7939,is a focal adhesion kinase-1(FAK)inhibitor with potential antiangiogenic and antineoplastic activities.FAK inhibitor GSK2256098 inhibits FAK,which may prevent the integrin-mediated activation of several downstream signal transduction pathways,including ERK,JNK/MAPK and PI3K/Akt,thereby inhibiting tumor cell migration,proliferation and survival,and tumor angiogenesis.The tyrosine kinase FAK is normally activated by binding to integrins in the extracellular matrix(ECM)but may be upregulated and constitutively activated in various tumor cell types.	price>
R-R-2940	Praliciguat CAS No.1628730-49-3	Praliciguat (IW-1973)/CAS No.1628730-49-3 is a potent and orally active soluble guanylate cyclase stimulator, enhances NO signaling, acts as a vasodilator. Praliciguat (IW-1973) stimulates sGC in HEK-293 cells with an EC50 of 197 nM.	price>
R-C-1241	Cobimetinib(gdc0973,XL518,RG7420) CAS No. 934660-93-2	Cobimetinib (GDC-0973,RG7420)is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM,showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases.Cobimetinib induces apoptosis.	price>
R-R-2941	Olinciguat CAS No.1628732-62-6	Olinciguat (IW-1701)/CAS No.1628732-62-6 is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay.	price>
R-C-1242	GSK269962A CAS:850664-21-0	GSK269962A(GSK 269962)is a potent ROCK inhibitor with IC50s of 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively.GSK269962A has anti-inflammatory and vasodilatory activities.	price>
R-R-2942	Indusatumab CAS No.1497400-26-6	Indusatumab (5F9 Monoclonal antibody)/CAS No.1497400-26-6 is an anti-human GUCY2C (Guanylate cyclase 2C) monoclonal antibody.	price>
R-C-1243	CPI-169 CAS:1450655-76-1	CPI-169(CPI 169 R-enantiomer)is a novel and potent EZH2 inhibitor,with IC50s of 0.24 nM,0.51 nM,and 6.1nM for EZH2 WT,EZH2 Y641N,and EZH1,respectively.	price>
R-R-2943	LY83583 CAS No.91300-60-6	LY83583/CAS No.91300-60-6 is a cell-permeable and competitive inhibitor of soluble guanylate cyclase (sGC) with an IC50 value of 2 µM.	price>
R-C-1244	cpi-360 CAS:1802175-06-9	CPI-360 is a selective EZH2 inhibitor with IC50 values of 0.5 and 2.5 nM for wild-type EZH2 and Y641N mutant EZH2,respectively.	price>
R-R-2944	Zagociguat CAS No.2201048-82-8	Zagociguat/CAS No.2201048-82-8 is the stimulator of soluble guanylate cyclase. Zagociguat increases nitric oxide (NO) signaling leading to an increase in cyclic guanosine monophosphate production. Zagociguat has the potential for the research of noncentral nervous system (CNS) disorders.	price>
R-C-1245	u73122 CAS:112648-68-7	U-73122 is a potent phospholipase C inhibitor or PI-PLC inhibitor.U-73122 is widely used as a tool to investigate the involvement of the phosphoinositide-specific phospholipase C(PLC)in signal transduction,particularly in studies attempting to characterize pathways leading to intracellular Ca2+ mobilization upon agonist challenge.U-73122 directly blocks PLC isoenzymes in vivo and in vitro.	price>
R-R-2945	Plecanatide CAS No.467426-54-6	Plecanatide/CAS No.467426-54-6, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide shows anti-inflammatory activity in models of murine colitis.	price>
R-C-1246	Arry-520 (Filanesib) CAS:885060-09-3	Filanesib,also known as ARRY-520,is a synthetic,small molecule targeting the kinesin spindle protein(KSP)with potential antineoplastic activity.KSP inhibitor ARRY-520 specifically inhibits KSP(kinesin-5 or Eg5),resulting in activation of the spindle assembly checkpoint,induction of cell cycle arrest during the mitotic phase,and consequently cell death in tumor cells that are actively dividing.KSP is an ATP-dependent microtubule motor protein that is essential for the formation of bipolar spindles and the proper segregation of sister chromatids during mitosis.	price>

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