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Catalog	name	Description	price
R-C-1261	YL-109 CAS ： 36341-25-0	YL-109 has ability to inhibit breast cancer cell growth and invasiveness in vitro and in vivo.YL-109 repressed the sphere-forming ability and the expression of stem cell markers in MDA-MB-231 mammosphere cultures.YL-109 increased the expression of carboxyl terminus of Hsp70-interacting protein(CHIP),which suppresses tumorigenic and metastatic potential of breast cancer cells by inhibiting the oncogenic pathway.YL-109 induced CHIP transcription because of the recruitment of the aryl hydrocarbon receptor(AhR)to upstream of CHIP gene in MDA-MB-231 cells.Consistently,the antitumor effects of YL-109 were depressed by CHIP or AhR knockdown in MDA-MB-231 cells.YL-109 inhibits cell growth and metastatic potential by inducing CHIP expression through AhR signaling and reduces cancer stem cell properties in MDA-MB-231 cells.	price>
R-R-2961	BI-2852 CAS No.2375482-51-0	BI-2852/CAS No.2375482-51-0 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 μM). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.	price>
R-C-1262	GSK 525762A (I-BET-762) CAS：1260907-17-2	GSK-525762A is a small molecule inhibitor of the BET(Bromodomain and Extra-Terminal)family.	price>
R-R-2962	BI-2493 CAS No.2937344-16-4	BI-2493/CAS No.2937344-16-4 is a structural analogue of BI-2865 and a highly selective pan-KRAS inhibitor. BI-2493 can attenuate tumor growth. BI-2493 can be used for cancer iseases research.	price>
R-C-1263	AM251 CAS：183232-66-8	AM251 is a potent CB1 receptor antagonist(IC50=8 nM,Ki=7.49 nM)that displays 306-fold selectivity over CB2 receptors.	price>
R-R-2963	LUNA18 CAS No.2676177-63-0	LUNA18/CAS No.2676177-63-0 is an orally active KRAS inhibitor with an IC50 of ＜2 nM against KRASG12D-SOS. LUNA18 can be used for the research of cancer.	price>
R-C-1264	NSC 687852 (b-AP15) CAS：1009817-63-3	b-AP15 is a novel inhibitor of proteasome deubiquitination.b-AP15 displays antitumor activity in several preclinical,solid tumor models.b-AP15 triggers time-and dose-dependent apoptosis of the human multiple myeloma(MM)cell lines RPMI8226 and U266,as determined by phosphatidylserine exposure.b-AP15 may have potential for treatment of multiple myeloma patients.	price>
R-R-2964	BI-3406 CAS No.2230836-55-0	BI-3406 (compound I-6)/CAS No.2230836-55-0 is an orally active, highly potent and selective inhibitor of the interaction between KRAS and Son of Sevenless 1 (SOS1) with an IC50 of 6 nM. BI-3406 potently reduces the formation of GTP-loaded KRAS, and inhibits MAPK pathway signaling. BI-3406 has anticancer activity.	price>
R-C-1265	BIX 01294 CAS：1392399-03-9	BIX01294 is a potent chemical inhibitor of G9a methyltransferase that catalyzes the mono-and di-methylation of the lysine 9 residue of histone H3.BIX01294 suppresses osteoclast differentiation on mouse macrophage-like Raw264.7cells. BIX01294 enhances the cardiac potential of bone marrow cells.	price>
R-R-2965	NSC 23766 trihydrochloride CAS No.1177865-17-6	NSC 23766 trihydrochloride/CAS No.1177865-17-6 is an inhibitor of Rac1 activation.	price>
R-C-1266	LDN-57444 CAS：668467-91-2	LDN-57444 is a Uch-L1 inhibitor(ubiquitin C-terminal hydrolase-L1)with Ki=0.4 μ M.Ubiquitin carboxy-terminal hydrolase L1(UCH-L1)is an intracellular protein abundantly expressed in neurons,and a mutation in UCH-L1 has been identified in familial Parkinson is disease.	price>
R-R-2966	CID-1067700 CAS No.314042-01-8	CID-1067700 (ML282)/CAS No.314042-01-8 is a pan GTPase inhibitor, and competitively inhibits Ras-related in brain 7 (Rab7) with a Ki of 13 nM.	price>
R-C-1267	Kenpaullone CAS：142273-20-9	Kenpaullone is a potent inhibitor of CDK1/cyclin B(IC50=400 nM),CDK2/cyclin A (IC50=680 nM),CDK2/cyclin E(IC50=7.5uM)and CDK5/p25(IC50=850 nM).Kenpaullone inhibits CDK2/cyclin A,CDK2/cyclin E and CDK5/cyclin/p35(IC50 values are 0.68, 7.5 and 0.85 μM respectively).	price>
R-R-2967	Lonafarnib CAS No.193275-84-2	Lonafarnib (Sch66336)/CAS No.193275-84-2 is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC50 values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities.	price>
R-C-1268	GSK3787 CAS：188591-46-0	GSK-3787 is a selective and irreversible peroxisome proliferator-activated receptor delta(PPARdelta)antagonist with good pharmacokinetic properties. GSK3787 can antagonize PPARbeta/delta in vivo,thus providing a new strategy to delineate the functional role of a receptor with great potential as a therapeutic target for the treatment and prevention of disease.	price>
R-R-2968	Divarasib CAS No.2417987-45-0	Divarasib (GDC-6036)/CAS No.2417987-45-0 is an orally bioavailable, highly potent, and selective KRAS G12C inhibitor with an IC50 of <0.01 μM. Divarasib covalently binds to the switch II (SW-II) pocket of KRAS G12C and irreversibly locks it in the inactive GDP-bound state.	price>
R-C-1269	L-779450 CAS： 303727-31-3	L-779450 is a potent,selective and ATP-competitive Raf kinase inhibitor(IC50=10 nM).L-779450 suppresses DNA synthesis and induces apoptosis in cells that proliferate in response to Raf-1 and A-Raf but not B-Raf.	price>
R-R-2969	BAY-293 CAS No.2244904-70-7	BAY-293/CAS No.2244904-70-7, a valuable chemical probe, blocks RAS activation via disruption of the KRAS-SOS1 interaction with an IC50 of 21 nM. BAY-293 is a potent inhibitor of Son of Sevenless 1 (SOS1). SOS1 is the guanine nucleotide exchange factor (GEF) and activator of RAS.	price>
R-C-1270	AZD2858 CAS：486424-20-8	AZD2858 is a potent and GSK-3 inhibitor with an IC50 of 68 nM.AZD-2858 inhibits tau phosphorylation at the S396 site,and it activates Wnt signaling pathway. AZD2858 has a substantial impact on fracture healing.The fractures healed with a bony callus without an obvious endochondral component,suggesting that AZD2858 drives mesenchymal cells into the osteoblastic pathway.	price>
R-R-2970	GGTI298 Trifluoroacetate CAS No.1217457-86-7	GGTI298 Trifluoroacetate/CAS No.1217457-86-7 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, which can inhibit Rap1A with IC50 of 3 μM; little effect on Ha-Ras with IC50 of >20 μM.	price>

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