Xi'an ruixi Biological Technology Co

Home > Keywords >

Catalog	name	Description	price
R-R-2946	(Rac)-MGV354 CAS No.1852495-86-3	(Rac)-MGV354/CAS No.1852495-86-3 is the racemate of MGV354. MGV354 is a soluble guanylate cyclase (sGC) activator with EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively.	price>
R-C-1247	DBeQ CAS：177355-84-9	DBeQ,also known as JRF 12,is a selective,reversible,and ATP-competitive inhibitor of the ATPase p97 for treatment of cancer.DBeQ impairs both ubiquitin-dependent and autophagic protein clearance pathways.DBeQ was shown to inhibit the ATPase activity of Vps4 with an IC50 of about 11.5 μM.To a less degree,it also inhibits hyphal growth.DBeQ blocks multiple processes that have been shown by RNAi to depend on p97,including degradation of ubiquitin fusion degradation and endoplasmic reticulum-associated degradation pathway reporters,as well as autophagosome maturation.	price>
R-R-2947	BAY 41-8543 CAS No.256498-66-5	BAY 41-8543/CAS No.256498-66-5 is an orally active, nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC). BAY 41-8543 has vasodilator activity in the pulmonary and systemic vascular beds in the rat. BAY 41-8543 has antiplatelet effects and has the potential for cardiovascular diseases research.	price>
R-C-1248	Pseudolaric Acid B(PBA) CAS： 82508-31-4	Pseudolaric Acid B is a diterpene isolated from the root of Pseudolarix kaempferi Gorden(pinaceae),has anti-cancer,antifungal,and antifertile activities,and shows immunosuppressive activity on T lymphocytes.Pseudolaric Acid B inhibits hepatitis B virus(HBV)secretion through apoptosis and cell cycle arrest.Pseudolaric Acid B induces autophagy.	price>
R-R-2948	BAY-747 CAS No.1609342-18-8	BAY-747/CAS No.1609342-18-8 is an orally active and brain-penetrant stimulator of soluble guanylate cyclase (sGC). BAY-747 reverses L-NAME induced memory impairments and enhances cognition of rats in the object location task (OLT). BAY-747 also decreases blood pressure in both conscious normotensive and spontaneously hypertensive rats (SHR). BAY-747 improves function of the skeletal muscle associated with Duchenne muscular dystrophy (DMD) in mdx/mTRG2 mice model.	price>
R-C-1249	BIIB021(CNF2024) CAS：848695-25-0	BIIB021 is an oral fully synthetic Hsp90 inhibitor that selectively and potently inhibits the molecular chaperone Hsp90 thereby inhibiting the proper assembly of multiple oncogenic proteins involved in tumor growth and survival.	price>
R-R-2949	Nelociguat CAS No.625115-52-8	Nelociguat (BAY60-4552)/CAS No.625115-52-8 is a nitric oxide sensitive soluble guanylate cyclase stimulator.	price>
R-C-1250	GLPG0634 analogue CAS：1206101-20-3	GLPG0634-analogue is an analogue of Filgotinib or GLPG0634,is a potent and selective JAK1 inhibitor.	price>
R-R-2950	Plecanatide acetate CAS No.1075732-84-1	Plecanatide acetate/CAS No.1075732-84-1, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide acetate activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide acetate can be used for the research of chronic idiopathic constipation, and it also shows anti-inflammatory activity in models of murine colitis.	price>
R-C-1251	TG003 CAS： 300801-52-9	TG003 is a potent and ATP-competitive Cdc2-like kinase(Clk)inhibitor with IC50 of 20 nM,200 nM,and 15 nM for Clk1,Clk2,and Clk4,respectively.No inhibitory effect on Clk3,SRPK1,SRPK2,or PKC.	price>
R-R-2951	MM 419447 CAS No.1092457-78-7	MM 419447/CAS No.1092457-78-7, a linaclotide metabolite, is a guanylate cyclase-C agonist. MM 419447 has the potential for the research of the irritable bowel syndrome with constipation (IBS-C).	price>
R-C-1252	Mdivi-1 CAS：338967-87-6	Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division dynamin-related GTPase(DRP1)and mitochondrial division dynamin I(Dnm1).Mdivi-1 inhibits apoptosis by inhibiting mitochondrial outer membrane permeabilization. Mdivi-1 is the first selective inhibitor of mitochondrial division dynamins. Mdivi-1 represents a class of therapeutics for stroke,myocardial infarction,and neurodegenerative diseases.	price>
R-R-2952	CFM 1571 hydrochloride CAS No.1215548-30-3	CFM 1571 hydrochloride/CAS No.1215548-30-3 is the stimulator of the nitric oxide receptor, soluble guanylate cyclase (sGC) with an EC50 and IC50 of 5.49 μM and 2.84 μM, respectively. Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by nitric oxide (NO). CFM 1571 hydrochloride has the potential for the research of cardiovascular and other diseases.	price>
R-C-1253	Tubastatin A(free base) CAS：1252003-15-8	Tubastatin A is a potent and selective HDAC6 inhibitor. Tubastatin A demonstrates 1093-fold selectivity over HDAC1(IC50 values of 15 nM for HDAC6 vs 16.4 µM for HDAC1).Tubastatin A was substantially more selective than the known HDAC6 inhibitor Tubacin at all isozymes except HDAC8.	price>
R-R-2953	Dolcanatide CAS No.1092457-65-2	Dolcanatide/CAS No.1092457-65-2 is an orally active GC-C (guanylate cyclase-C) agonist. Dolcanatide shows laxative, anti-nociceptive and anti-inflammatory activity. Dolcanatide can be used in inflammatory bowel disease research.	price>
R-C-1254	CCT007093 CAS：176957-55-4	CCT007093 is an effective protein phosphatase 1D(PPM1D Wip1)inhibitor.Wip1 inhibition can activate the mTORC1 pathway and enhance hepatocyte proliferation after hepatectomy.	price>
R-R-2954	Guanylin(human) TFA	Guanylin(human) TFA, a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator. Guanylin(human) TFA is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism.	price>
R-C-1255	Quisinostat CAS:875320-29-9	SB-3CT is a potent matrix metalloproteinase MMP-2 and MMP-9 inhibitor.SB-3CT is a 2-[(arylsulfonyl)methyl]thiirane that achieves potent inhibition,by a thiirane-opening mechanism,of the MMP2 and MMP9 zinc metalloproteases.SB-3CT attenuates behavioral impairments and hippocampal loss after traumatic brain injury in rat.Matrix metalloproteinases(MMPs)are involved in a number of activities including angiogenesis and embryogenesis.In particular,gelatinases A (MMP-2)and B(MMP-9),are thought to facilitate tumor metastasis.	price>
R-R-2955	Ebselen oxide CAS No.104473-83-8	Ebselen oxide/CAS No.104473-83-8, the selenone analogue of Ebselen, covalently modifies diguanylate cyclase (DGC) to inhibit c-di-GMP-receptor interactions and reduces DGC activity. Ebselen oxide also inhibits alginate production (IC50=14 μM) by Pseudomonas aeruginosa. Ebselen oxide inhibits HDAC1, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, and HDAC9 (IC50 ranging from 0.2 to 4.7 μM).	price>
R-C-1256	Rimonabant CAS:168273-06-1	Rimonabant(SR141716)is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane.Rimonabant is also a dual inhibitor of acyl CoA:cholesterol acyltransferases(ACAT)1 and 2 and inhibits mycobacterial MmpL3.	price>

505506507508509510 511512513514515