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Catalog	name	Description	price
R-C-1307	Prexasertib HCl (LY2606368) CAS：1234015-54-3	Prexasertib(LY2606368)is an ATP-competitive CHK1 inhibitor with a Ki value of 0.9 nmol/L.For CHK2 and RSK,its IC50 values are 8 nM and 9 nM respectively in cell-free assay.	price>
R-R-3007	KRAS G12C inhibitor 19 CAS No.2649788-46-3	KRAS G12C inhibitor 19/CAS No.2649788-46-3 is a potent inhibitor of KRAS G12C. KRAS G12C inhibitor 19 significantly inhibits tumor growth (extracted from patent WO2021118877A1).	price>
R-C-1308	ODM201 CAS：1297538-32-9	ODM-201,also known as Darolutamide,ODM-201 is a full and high-affinity AR antagonist that,similar to second-generation antiandrogens enzalutamide and ARN-509,inhibits testosterone-induced nuclear translocation of AR.Importantly,ODM-201 also blocks the activity of the tested mutant ARs arising in response to antiandrogen therapies.	price>
R-R-3008	MRTX-EX185 formic	MRTX-EX185 formic is a potent inhibitor of GDP-loaded KRAS and KRAS(G12D), with an IC50 of 90 nM for KRAS(G12D). MRTX-EX185 formic also binds GDP-loaded HRAS. MRTX-EX185 (formic) is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-1309	WP1066 CAS:857064-38-1	WP1066 is a Stat3 inhibitor and JAK2 inhibitor.WP1066 is also a novel analogue of the JAK2 inhibitor AG490,in JAK2 V617F-positive erythroleukemia HEL cells and in blood cells from patients with polycythemia vera.WP1066 significantly inhibited JAK2 and its downstream signal transducer and activator of transcription-3,signal transducer and activator of transcription-5,and extracellular signal-regulated kinase-1/2 pathways in a dose-and time-dependent manner.	price>
R-R-3009	KRAS inhibitor-3 CAS No.900897-56-5	KRAS inhibitor-3/CAS No.900897-56-5 is an inhibitor of KRAS inhibitor. KRAS inhibitor-3 binds to WT and oncogenic KRAS mutants with high affinity (KD: 0.28 μM for KRAS WT, 0.63 μM for KRAS G12C, 0.37 μM for KRAS G12D, 0.74 μM for KRAS Q61H). KRAS inhibitor-3 also disrupts interaction of KRAS with Raf.	price>
R-C-1310	Domatinostat (4SC-202） CAS：910462-43-0	Domatinostat(4SC-202 free base)is a selective class I HDAC inhibitor with IC50 of 1.20 μM,1.12 μM,and 0.57 μM for HDAC1,HDAC2,and HDAC3, respectively.It also displays inhibitory activity against Lysine specific demethylase 1(LSD1).	price>
R-R-3010	CID44216842 CAS No.1222513-26-9	CID44216842 (Cdc42-IN-1)/CAS No.1222513-26-9 is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding assay, respectively. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 0.3 and 0.5 μM in GDP binding assay, respectively. Use as a molecular probe.	price>
R-R-3011	MCP110 CAS No.521310-51-0	MCP110/CAS No.521310-51-0 is an inhibitor of Ras/Raf-1 interaction. MCP110 blocks the interaction of Ras with Raf. MCP110 disrupts this interaction might can be used for the research of human tumors.	price>
R-C-1311	umi-77 CAS ：518303-20-3	UMI-77 is a selective Mcl-1 inhibitor,which shows high binding affinity to Mcl-1(IC50=0.31μM).UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM,showing selectivity over other members of anti-apoptotic Bcl-2 members.	price>
R-C-1312	SQ109 CAS：502487-67-4	SQ109 is a drug undergoing development for treatment of tuberculosis.SQ109 showed activity against both drug susceptible and Multi-drug-resistant tuberculosis bacteria,including Extensively drug-resistant tuberculosis strains. In preclinical studies SQ109 enhanced the activity of anti-tubercular drugs isoniazid and rifampin and reduced by >30% the time required to cure mice of experimental TB.SQ109 is being developed by OOO Infectex in Russia and by Sequella Inc internationally.I	price>
R-R-3012	ESI-08 CAS No.301177-43-5	ESI-08/CAS No.301177-43-5 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC50 of 8.4 μM) activity. ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation.	price>
R-C-1313	Ilomastat (GM6001, Galardin) CAS:142880-36-2	Ilomastat,also known as GM6001 and galardin,is a broad-spectrum matrix metalloproteinase inhibitor with potential anticancer activity.GM6001 is a member of the hydroxamic acid class of reversible metallopeptidase inhibitors. The anionic state of the hydroxamic acid group forms a bidentate complex with the active site zinc.Examples of enzymes that ilomastat inhibit include thermolysin,peptide deformylase,and anthrax lethal factor endopeptidase(LF) produced by the bacterium Bacillus anthracis.	price>
R-R-3013	ASP2453 CAS No.2241719-73-1	ASP2453/CAS No.2241719-73-1 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC50 value of 40 nM.	price>
R-C-1314	AMG337 CAS:1173699-31-4	AMG-337 is a potent and highly selective small molecule ATP-competitive MET kinase inhibitor.AMG 337 inhibits MET kinase activity with an IC50 of<5nM in enzymatic assays.	price>
R-R-3014	Y16 CAS No.429653-73-6	Y16/CAS No.429653-73-6 is a specific inhibitor of Leukemia-associated Rho guanine nucleotide exchange factor (LARG) with a Kd value of 76 nM. Y16 is active in blocking the interaction of LARG and related G-protein-coupled Rho GEFs with RhoA. Y16 shows no detectable effect on other diffuse B-cell lymphoma (Dbl) family Rho GEFs, Rho effectors, or a RhoGAP.	price>
R-C-1315	RG2833 (RGFP109) CAS:1215493-56-3	RG2833 is a brain-penetrant HDAC inhibitor with IC50s of 60 nM and 50 nM for HDAC1 and HDAC3,respectively.The Ki values for HDAC1 and HDAC3 are 32 and 5 nM, respectively.	price>
R-R-3015	K-Ras(G12C) inhibitor 12 CAS No.1469337-95-8	K-Ras(G12C) inhibitor 12/CAS No.1469337-95-8 is a K-Ras(G12C) inhibitor, the half-maximum effective concentration (EC50) for K-Ras(G12C) inhibitor 12 in H1792 cells is 0.	price>
R-C-1316	GSK0660 CAS:1014691-61-2	GSK0660 is a potent PPARβ/δ antagonist with a pIC50 of 6.8(binding assay IC50 =155 nM;antagonist assay IC50=300nM)and is nearly inactive on PPARα and PPARγ with IC50s above approximately 10 μM.GSK0660(100nM)reduces CPT1a(a PPARβ/δ target gene)expression below the basal vehicle-treated level by approximately 50%,but shows no effect on PDK4 expression,which is also a PPARβ/δ target gene in skeletal muscle cells.GSK0660(0.5μM)reduces the levels of AMPK and eNOS phosphorylation,and BMP-2,Runx-2 mRNA expression in MC3T3-E1 cells.	price>
R-R-3016	KRas G12R inhibitor 1	KRas G12R inhibitor 1 (compound 3) is a KRas G12R selective covalent inhibitor that exploits the strong nucleophilicity of mutant cysteines and binds irreversibly in the Switch II region of K-Ras. KRas G12R inhibitor 1 can be used in cancer research.	price>

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