Product apis-apoptosis

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Catalog	name	Description	price
R-C-1390	Nutlin-3 CAS：890090-75-2	Nutlin-3,also known as(±)-Nutlin-3 and N-6287,is a p53-Mdm2 Antagonist for Nasopharyngeal Carcinoma Treatment.Nutlin-3 specifically targets p53-Mdm2 interaction offers new therapeutic opportunities by enhancing cancer cell growth arrest and apoptosis through the restoration of the p53-mediated tumor suppression pathway while producing minimal cytotoxicity and side effects. Nutlin-3 reverses the epithelial-mesenchymal transition in gemcitabine-resistant hepatocellular carcinoma cells.Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity.	price>
R-C-1502	ML281 CAS:1404437-62-2	ML-281 is a potent ans selective STK33 inhibitor(IC50=14 nM).ML281 showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK33 inhibitors.ML281 is a valuable addition to small-molecule probes of STK33.v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(KRAS)is the most mutated oncogene, and KRAS mutations have been found in up to 20% of all human tumors.STK33 was selectively toxic to KRAS-dependent cancer cell lines,suggesting that small-molecule inhibitors of STK33 might selectively target KRAS-dependent cancers.	price>
R-C-1513	Tenovin-6 CAS：1011557-82-6	Tenovin-6 is a analog of tenovin-1.Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1,SIRT2,and SIRT3 in vitro with IC50 values of 21,10,and 67uM,respectively.	price>
R-C-1566	Selonsertib (GS-4997) CAS：1448428-04-3	Selonsertib is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1(ASK1),with potential anti-inflammatory,antineoplastic and anti-fibrotic activities.	price>
R-C-1568	Navitoclax (ABT-263) CAS：923564-51-6	Navitoclax(ABT-263)is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins,such as Bcl-xL,Bcl-2 and Bcl-w,with a Ki of less than 1nM.	price>
R-C-1575	QVD-oph CAS：1135695-98-5	Q-VD-OPh is an irreversible pan-caspase inhibitor with potent antiapoptotic properties;inhibits caspase 7 with an IC50 of 48 nM and 25-400 nM for other caspases including caspase 1,3,8,9,10,and 12.Q-VD-OPh can inhibits HIV infection.Q-VD-OPh is able to cross the blood-brain barrier.	price>
R-C-1617	GW4869 CAS:6823-69-4	GW4869(GW69A,GW554869A)is a neutral,noncompetitive inhibitor of sphingomyelinase (SMase)with an IC50 of 1μM.It is selective for N-SMase,and does not inhibit acid SMase at up to at least 15μM.	price>
R-C-1647	Importazole CAS:662163-81-7	Importazole is a small molecule inhibitor of the transport receptor importin-β (Karyopherin beta)specifically blocking importin-β-mediated nuclear import. Importazole induces apoptosis and inhibits tumor growth.	price>
R-C-1665	NSC303580 CAS：64984-31-2	Pifithrin-μ(NSC 303580,PFTμ,2-Phenylethynesulfonamide)is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2,and also inhibits HSP70 function and autophagy.	price>
R-C-1667	TPEN CAS：16858-02-9	TPEN is a heavy metal chelator.Reacts with both Zn-proteome and Zn-metallothionein(MT)in LLC-PK1 cells;acts as an intracellular chelator of proteomic Zn2+.	price>

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