Product apis-apoptosis

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Catalog	name	Description	price
R-C-1956	FCCP CAS:370-86-5	FCCP is an uncoupler of oxidative phosphorylation(OXPHOS)in mitochondria.FCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation.	price>
R-C-1959	GSK583 CAS： 1346547-00-9	GSK583 is a highly potent,orally active and selective inhibitor of RIP2 Kinase,with IC50 of 5nM.GSK583 inhibits both TNF-α and IL-6 production with an IC50 value of 200nM.	price>
R-C-1970	Prima-1 CAS：5608-24-2	PRIMA-1(NSC-281668)is a mutant p53 reactivator,restores the sensitivity of TP53 mutant-type thyroid cancer cells to the histone methylation inhibitor 3-Deazaneplanocin A.	price>
R-C-1978	HS1371 CAS：2158197-70-5	HS-1371 is a novel kinase inhibitor of RIP3-mediated necroptosis.HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner, providing a mechanism of action.Moreover,the compound inhibited TNF-induced necroptosis but did not inhibit TNF-induced apoptosis,indicating that this novel inhibitor has a specific inhibitory effect on RIP3-mediated necroptosis via the suppression of RIP3 kinase activity.	price>
R-C-2006	S-GBOXIN CAS:2101317-21-7	S-Gboxin is an active analogue of Gboxin with potent antitumour activity.S-Gboxin inhibits growth of mouse and human glioblastoma(GBM)with an IC50 of 470 nM.Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma. Gboxin inhibits the growth of primary mouse and human glioblastoma cells but not that of mouse embryonic fibroblasts or neonatal astrocytes.	price>
R-C-2019	GSK2982772 CAS：1622848-92-3	GSK2982772 is a potent,orally active and ATP competitive RIP1 kinase inhibitor with IC50 values of 16nM and 20nM for human and monkey RIP1,respectively.	price>
R-C-2085	Q-VD-OPh hydrate CAS:1135695-98-5	Q-VD-OPh is an irreversible pan-caspase inhibitor with potent antiapoptotic properties,inhibits caspase 7 with an IC50 of 48nM and 25-400nM for other caspases including caspase 1,3,8,9,10,and 12.Q-VD-OPh can inhibits HIV infection.Q-VD-OPh is able to cross the blood-brain barrier.	price>
R-C-2086	GSK2983559 FREE ACID CAS:1579965-12-0	GSK2983559 free acid(compound 3)is a potent,specific and oral active receptor interacting protein 2(RIP2)kinase inhibitor.GSK2983559 free acid has excellent activity in blocking many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples.	price>
R-C-2121	PK11007 CAS： 874146-69-7	PK11007 is a mild thiol alkylator with anticancer activity.PK11007 stabilizes p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity.PK11007 induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS)levels.	price>
R-C-2127	BBT594 CAS：882405-89-2	BBT594(NVP-BBT594)is potent and selective RET and JAK2 inhibitor.NVP-BBT594 impairs GDNF-RET signaling and GDNF-dependent growth of MCF7-LTED cells.NVP-BBT594 targets GDNF-RET signaling and sensitizes MCF7-2A cells to letrozole treatment.GDNF-RET signaling as a rational therapeutic target may be useful to combat or delay the onset of AI resistance in breast cancer.	price>

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