Product apis-epigentics

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Catalog	name	Description	price
R-C-756	EPZ5676 cas:1380288-87-8	Pinometostat(EPZ5676)is an S-adenosyl methionine(SAM)competitive inhibitor of protein methyltransferase DOT1L with Ki of 80 pM in a cell-free assay, demonstrating >37,000-fold selectivity against all other PMTs tested,inhibits H3K79 methylation in tumor.	price>
R-R-2456	IACS-9571 hydrochloride CAS No.2319611-93-1	IACS-9571 (ASIS-P040) hydrochloride/CAS No.2319611-93-1 is a potent and selective inhibitor of TRIM24 and BRPF1, with an IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.	price>
R-R-2457	VZ185 CAS No.2306193-61-1	VZ185/CAS No.2306193-61-1 is a potent, fast, and selective von Hippel-Lindau based dual degrader probe of BRD9 and BRD7 with DC50s of 4.5 and 1.8 nM, respectively. VZ185 is cytotoxic in EOL-1 and A-402 cells, with EC50s of 3 nM and 40 nM, respectively.	price>
R-R-2458	(R)-(-)-JQ1 Enantiomer CAS No.1268524-71-5	(R)-(-)-JQ1 Enantiomer/CAS No.1268524-71-5 is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (R)-(-)-JQ1 Enantiomer has no effect.	price>
R-R-2459	GNE-049 CAS No.1936421-41-8	GNE-049/CAS No.1936421-41-8 is a highly potent and selective CBP inhibitor with an IC50 of 1.1 nM in TR-FRET assay. GNE-049 also inhibits BRET and BRD4(1) with IC50s of 12 nM and 4200 nM, respectively.	price>
R-C-760	sgc0946 CAS No. 1561178-17-3	SGC0946 is a highly potent and selective DOT1L methyltransferase inhibitor with IC50 of 0.3 nM;selectively kill mixed lineage leukaemia cells.	price>
R-R-2460	FHT-1015 CAS No.2368903-18-6	FHT-1205/CAS No.2368903-18-6 is a potent SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor with IC50s of ≤10 nM (WO2020160180A1; compound 67).	price>
R-R-2461	GSK2801 CAS No.1619994-68-1	GSK2801/CAS No.1619994-68-1 is a potent, selective, orally active and cell active acetyl-lysine competitive BAZ2A and BAZ2B bromodomains inhibitor with Kd values of 136 nM and 257 nM, respectively. GSK2801 shows >50-fold selectivity for BAZ2A/B over BRD4.	price>
R-R-2462	BRD4 degrader AT1 CAS No.2098836-45-2	BRD4 degrader AT1/CAS No.2098836-45-2 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4 as a highly selective Brd4 degrader, with a Kd of 44 nM for Brd4BD2 in cells.	price>
R-R-2463	BAY-299 CAS No.2080306-23-4	BAY-299/CAS No.2080306-23-4 is a very potent, dual inhibitor with IC50s of 67 nM for BRPF2 bromodomains (BD), 8 nM for TAF1 BD2, and 106 nM for TAF1L BD2.	price>

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