Product apis-neuronal-signaling

Home > products > apis> neuronal-signaling

Catalog	name	Description	price
R-C-600	Celecoxib cas:169590-42-5	Celecoxib(SC 58635) is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells.	price>
R-C-617	VU0357121 cas:433967-28-3	VU 0357121 is a positive and highly selective mGlu5R allosteric modulator(PAM) with an EC50 of 33 nM.VU 0357121 is inactive or very weakly antagonizing at other mGlu receptor subtypes.	price>
R-C-629	Tarafenacin cas:385367-47-5	Tarafenacin is a highly selective M3 muscarinic receptor antagonist.It was the most potent in inhibiting carbachol-induced bladder contractions of the anti-cholinergic agents tested,without affecting atrial contractions over the same range of concentrations.	price>
R-C-663	VALDECOXIB cas:181695-72-7	Valdecoxib is a sulfonamide derivative and non-steroidal anti-inflammatory drug (NSAID)with anti-inflammatory,analgesic,and antipyretic activities.Valdecoxib selectively binds to and inhibits cyclooxygenase (COX)-2,thereby preventing the conversion of arachidonic acid into prostaglandins,which are involved in the regulation of pain,inflammation,and fever.This NSAID does not inhibit COX-1 at therapeutic concentrations and therefore does not interfere with blood coagulation.	price>
R-C-664	Parecoxib 198470-84-7	Parecoxib(SC 69124)is a highly selective and orally active COX-2 inhibitor,the prodrug of Valdecoxib(HY-15762).Parecoxib Sodium is a nonsteroidal anti-inflammatory agent(NSAID)and inhibits prostaglandin(PG)synthesis.Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.	price>
R-C-718	AWD 131-138 CAS:188116-07-6	AWD 131-138(Imepitoin,ELB-138) is a centrally acting anti-epileptic which crosses the blood brain barrier and is used for the treatment of canine idiopathic epilepsy.AWD 131-138(Imepitoin)is an antiepileptic and antianxietic drug,AWD 131-138 can stimulate different recombinant isoforms of the rat GABA(A) receptor through the benzodiazepine binding site.	price>
R-C-722	Ampalex (CX-516) CAS:154235-83-3	CX516(BDP 12)is an ampakine and acts as an AMPA receptor positive allosteric modulator for the research of Alzheimer is disease,schizophrenia and mild cognitive impairment(MCI).	price>
R-C-726	Huperzine A CAS：102518-79-6	(-)-Huperzine A is a potent,highly specific and reversible inhibitor of acetylcholinesterase (AChE)with Ki of 7 nM,exhibiting 200-fold more selectivity for G4 AChE over G1 AChE.Also acts as an NMDA receptor antagonist.	price>
R-C-1023	CW069 CAS No. 1594094-64-0	CW069 is a novel allosteric inhibitor of microtubule kinesin hset.Its IC50 value is 75±20μm,which is significantly selective compared with KSP.IC50 value:75 ± 20μm[1]target:hset-cw069 has obvious selectivity for hset in vitro.The IC50 value of cw069 for hset was 75±20μm,and the selectivity of cw069 for KSP reached the experimental limit.CW069 induced a small but significant increase in the multipolar spindle of MDA-MB-231,which was consistent with the intermediate level of centrosome in untreated cells.After cw069 treatment,the number of multipolar spindles increased in bt549 cells.	price>
R-C-1028	SVT-40776 CAS NO. 385367-47-5	SVT-40776 is a potent inhibitor of M(3)receptor-related detrusor contractile activity.SVT-40776 is highly selective for M(3) over M(2)receptors(Ki=0.19 nmol.L(-1)for M(3)receptor affinity).SVT-40776 was the most potent in inhibiting carbachol-induced bladder contractions of the anti-cholinergic agents tested, without affecting atrial contractions over the same range of concentrations. SVT-40776 exhibited the highest urinary versus cardiac selectivity(199-fold).	price>

...