Product apis-proteases

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Catalog	name	Description	price
R-C-1255	Quisinostat CAS:875320-29-9	SB-3CT is a potent matrix metalloproteinase MMP-2 and MMP-9 inhibitor.SB-3CT is a 2-[(arylsulfonyl)methyl]thiirane that achieves potent inhibition,by a thiirane-opening mechanism,of the MMP2 and MMP9 zinc metalloproteases.SB-3CT attenuates behavioral impairments and hippocampal loss after traumatic brain injury in rat.Matrix metalloproteinases(MMPs)are involved in a number of activities including angiogenesis and embryogenesis.In particular,gelatinases A (MMP-2)and B(MMP-9),are thought to facilitate tumor metastasis.	price>
R-C-1266	LDN-57444 CAS：668467-91-2	LDN-57444 is a Uch-L1 inhibitor(ubiquitin C-terminal hydrolase-L1)with Ki=0.4 μ M.Ubiquitin carboxy-terminal hydrolase L1(UCH-L1)is an intracellular protein abundantly expressed in neurons,and a mutation in UCH-L1 has been identified in familial Parkinson is disease.	price>
R-C-1278	LP-533401 CAS：945976-43-2	LP533401 is an inhibitor of tryptophan hydroxylase 1,which regulates serotonin production in the gut.LP533401 has an anabolic effect in bone.Inhibiting GDS biosynthesis could become a new anabolic treatment for osteoporosis.	price>
R-C-1313	Ilomastat (GM6001, Galardin) CAS:142880-36-2	Ilomastat,also known as GM6001 and galardin,is a broad-spectrum matrix metalloproteinase inhibitor with potential anticancer activity.GM6001 is a member of the hydroxamic acid class of reversible metallopeptidase inhibitors. The anionic state of the hydroxamic acid group forms a bidentate complex with the active site zinc.Examples of enzymes that ilomastat inhibit include thermolysin,peptide deformylase,and anthrax lethal factor endopeptidase(LF) produced by the bacterium Bacillus anthracis.	price>
R-C-1402	ABT530 CAS:1353900-92-1	Pibrentasvir(ABT-530)is a novel and pan-genotypic hepatitis C virus(HCV) NS5A inhibitor with EC50 ranging from 1.4 pM to 5.0 pM against HCV replicons containing NS5A from genotypes 1 to 6.	price>
R-C-1585	VR23 CAS : 1624602-30-7	VR23 is a small molecule that potently inhibited the activities of trypsin-like proteasomes(IC50=1nM),chymotrypsin-like proteasomes(IC50=50-100nM),and caspase-like proteasomes(IC50=3uM).	price>
R-C-1587	T-5224 CAS:530141-72-1	T-5224 is a selective inhibitor of transcription factor c-Fos/activator protein (AP)-1 with anti-inflammatory effects.T-5224 specifically inhibits the DNA binding activity of c-Fos/c-Jun and the IL-1β-induced up-regulation of Mmp-3,Mmp-13 and Adamts-5 transcription.	price>
R-C-1642	GSK1940029 CAS：1150701-66-8	GSK1940029(SCD inhibitor 1)is a stearoyl-coa desaturas(SCD)inhibitor extracted from patent WO/2009060053 A1,compound example 16.	price>
R-C-1643	FYX 051(Topiroxostat) CAS:577778-58-6	Topiroxostat(FYX-051)is a potent and orally active xanthine oxidoreductase (XOR)inhibitor with an IC50 value of 5.3 nM and a Ki value of 5.7nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity(18.6%).Topiroxostat has the potential for hyperuricemia treatment.	price>
R-C-1716	Telaglenastat (CB-839) CAS:1439399-58-2	Telaglenastat(CB-839)is a potent,selective,and orally bioavailable glutaminase inhibitor with IC50 of 24nM for recombinant human GAC.CB-839(Telaglenastat)inudces autophagy and has antitumor activity.	price>

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